Metabolic decisions in development and disease.

Development
Lluc MosteiroJelle van den Ameele

Abstract

The intimate relationships between cell fate and metabolism have long been recognized, but a mechanistic understanding of how metabolic pathways are dynamically regulated during development and disease, how they interact with signalling pathways, and how they affect differential gene expression is only emerging now. We summarize the key findings and the major themes that emerged from the virtual Keystone Symposium 'Metabolic Decisions in Development and Disease' held in March 2021.

References

Feb 24, 1956·Science·O WARBURG
May 29, 2009·The Journal of Biological Chemistry·Abdullah YalcinJason Chesney
May 9, 2014·Nature·Jing FanJoshua D Rabinowitz
Jul 28, 2015·Nature·Deniz SenyilmazAurelio A Teleman
Sep 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Chiao-Lin ChenNorbert Perrimon
Oct 10, 2015·Cell·Andrew P BaileyAlex P Gould
Oct 4, 2016·Cell·Michael MüllederMarkus Ralser
Oct 19, 2017·Nature·Sheng HuiJoshua D Rabinowitz
Aug 9, 2018·Nature Communications·Deniz Senyilmaz-TiebeAurelio A Teleman
Sep 13, 2019·Nature Metabolism·Santosha A VardhanaLydia W S Finley
Jan 10, 2020·Nature·Margarete Diaz-CuadrosOlivier Pourquié
May 27, 2020·Nature Cell Biology·Sanjeethan C BakshLydia W S Finley
Jun 26, 2020·Nature·Masayuki OginumaOlivier Pourquié
Nov 18, 2020·Nature Chemical Biology·Wei WeiJonathan Z Long
Mar 27, 2021·Nature Biotechnology·Christoph B MessnerMarkus Ralser
Jan 2, 2019·BioRxiv : the Preprint Server for Biology·L. RappezTheodore Alexandrov

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