PMID: 490626Jul 31, 1979Paper

Metabolic dependence of the offset of antidiuretic hormone-induced osmotic flow of water across the toad urinary bladder

The Journal of Membrane Biology
B R Masters, D D Fanestil

Abstract

The elevated osmotic permeability to water induced by antidiuretic hormone (ADH) in the isolated urinary bladder of the toad is rapidly reversed by removal or washout of the ADH. This return to normal water permeability is delayed by the suppression of production of metabolic energy by any of three maneuvers: (i) low temperature (2 degrees C); (ii) inhibition of oxidative phosphorylation (10 mM azide or 0.5 mM 2,4 dinitrophenol); or (iii) inhibition of glycolysis (10 mM iodoacetate or 10 mM 2-deoxyglucose). Moreover exposure to cytochalasin B, 2.1 X 10(-5) M, either before or after initiation of the hormonal effect also delays the return of water permeability to normal following removal of ADH. When considered within constraints imposed by models which predict ADH's action on water permeability to be either via modulation of the fluidity of lipids in the membrane or via the figuration of proteins ("pores") in the lipid membrane, these observations on the inhibition of the reversal of ADH stimulation of water flow are more consistent with the protein (pore) theory and place limitations on the mechanisms by which proteins in such pores can return to the resting or impermeable state.

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Citations

Jan 1, 1985·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J KipnowskiH J Kramer
Jan 1, 1982·The Journal of Membrane Biology·W A Kachadorian, S D Levine
Feb 2, 2000·Proceedings of the Society for Experimental Biology and Medicine·A DibasT Yorio
Jan 1, 1981·Annals of the New York Academy of Sciences·J B WadeS A Lewis
Jul 11, 1984·Biochimica Et Biophysica Acta·M S RubinS K Masur
May 1, 1986·The American Journal of Physiology·R BeauwensP A in't Veld
Jan 1, 1983·The American Journal of Physiology·P Eggena
Jan 1, 1983·The American Journal of Physiology·P Eggena

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