Metabolic determinants are much more important than genetic polymorphisms in determining the PAI-1 activity and antigen plasma concentrations: a family study with part of the Stanislas Cohort

Arteriosclerosis, Thrombosis, and Vascular Biology
M HenryI Juhan-Vague

Abstract

Increased plasma plasminogen activator inhibitor-1 (PAI-1) concentration has been identified as a risk factor for coronary heart disease. We investigated the relative contribution of both metabolic factors involved in the insulin resistance (IR) syndrome and polymorphisms of the PAI-1 gene to plasma levels of PAI-1 in 228 healthy nuclear white families from the Stanislas Cohort. Variables related to IR included body mass index, waist-to-hip ratio, fasting insulin, triglyceride, and HDL cholesterol. Five PAI-1 gene polymorphisms were studied, including a newly described G+12078A substitution in the 3' region. A sex difference was observed, with fathers exhibiting higher IR state and PAI-1 levels and stronger correlations between PAI-1 and IR variables than mothers. Such a difference was not observed in offspring. Family correlations were of similar magnitude for fibrinolytic parameters and IR variables. The PAI-1 genotypes A-844G, -675 4G/5G, and G+12078A polymorphisms, which were in strong linkage disequilibrium, were associated with plasma PAI-1 levels. In multivariate analysis, IR explained a major part of PAI-1 variability (49% in fathers, 29% in mothers), whereas polymorphisms had only a minor contribution, explaining 3% of...Continue Reading

References

Aug 1, 1990·American Journal of Epidemiology·O NilssenT Brenn
May 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·I Juhan-VagueD Collen
Oct 1, 1989·Metabolism: Clinical and Experimental·P CaronP Sié
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T NyD J Loskutoff
Jun 1, 1988·American Journal of Clinical Pathology·C KrishnamurtiB M Alving
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jul 1, 1981·American Journal of Epidemiology·A Donner, J J Koval
Sep 1, 1995·Metabolism: Clinical and Experimental·P Björntorp
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·P ErikssonA Hamsten
Apr 16, 1994·BMJ : British Medical Journal·H F HendriksC Kluft

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Citations

Sep 28, 2007·Rheumatology International·Nora Magdalena Torres-CarrilloJosé Francisco Muñoz-Valle
Dec 19, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maria FranziniRamachandran S Vasan
Feb 24, 2001·Lancet·M de LangeP J Grant
Mar 22, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·M S FreemanP J Grant
Jan 7, 2005·Journal of Thrombosis and Haemostasis : JTH·H R Lijnen
Nov 23, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mark D SternlichtZena Werb
Jan 23, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·C Ferrer-Antunes
Jan 26, 2016·Metabolic Syndrome and Related Disorders·Harry Robberecht, Nina Hermans
Mar 20, 2015·Disease Markers·Ilian Janet García-GonzálezJorge Ramón Padilla-Gutiérrez
Feb 24, 2000·The Journal of Pathology·P Carmeliet, D Collen
Jun 22, 2017·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Anna Janina EngstlerIna Bergheim
Feb 16, 2005·Human Heredity·Lyle G BestJean W Maccluer
Feb 12, 2008·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Norma Torres-CarrilloJosé Francisco Muñoz-Valle
Jul 4, 2006·Obstetrics and Gynecology·Mohamed A BedaiwyRobert F Casper
Jun 22, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Argirios E TsantesGeorgios Vaiopoulos
Feb 1, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·R J L MartinA P Maxwell
Dec 5, 2003·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Maria Teresa SartoriAntonio Girolami
May 4, 2013·Expert Review of Molecular Diagnostics·Simona SantangeloRaffaele Antonelli Incalzi
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·I Juhan-VagueP E Morange
Jul 16, 2003·Acta Neurologica Scandinavica·D PetrovicB Peterlin
Mar 31, 2004·Journal of Internal Medicine·A MavriI Juhan-Vague
May 12, 2001·Clinical Orthopaedics and Related Research·C J GlueckP Wang

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