Metabolic Determinants of Impaired Pulmonary Function in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
Martin RöhlingGDS study group

Abstract

Impaired lung function associates with deterioration of glycemic control and diabetes-related oxidative stress in long-standing type 2 diabetes. We hypothesized that recent-onset type 2 diabetes patients exhibit abnormal pulmonary function when compared to glucose-tolerant controls and that the frequencies of single-nucleotide polymorphisms (SNPs), known to associate with lung dysfunction, are different between both groups. Type 2 diabetes patients with a known disease duration<1 year (n=34) had similar age, sex distribution and BMI as overweight controls (n=26). Lung function was assessed by spirometry comprising predicted forced vital capacity (FVC%), predicted forced expiratory volume in one second (FEV1%) and the FEV1/FVC ratio. Multivariable linear regressions were performed to investigate group differences, which were adjusted for potential confounders such as age, sex, BMI, height and smoking status. SNP genotyping was conducted using real-time polymerase chain reaction-based allelic discrimination. Patients with type 2 diabetes had lower FEV1%, FEV1/FVC and VO2max (all p<0.05). Among patients with type 2 diabetes, FEV1% correlated positively with VO2max (r=0.40, p<0.05) and FEV1/FVC correlated negatively with HbA1c (r=-...Continue Reading

Citations

Jan 16, 2019·CNS Spectrums·Roger S McIntyreStephen M Stahl
Nov 24, 2018·CNS Spectrums·Zihang PanRoger S McIntyre
Jan 31, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Mei Chung MohSu Chi Lim
Aug 21, 2020·Journal of the American Geriatrics Society·Peifeng HuEileen M Crimmins
Aug 2, 2019·The International Journal of Cardiovascular Imaging·Vladan VukomanovicMarijana Tadic
Aug 18, 2020·Heart Failure Reviews·Marijana TadicCesare Cuspidi
Feb 12, 2021·ERJ Open Research·Jesús Díez-Manglano, Uxua Asìn Samper

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