Metabolic determinants of white matter hyperintensity burden in patients with ischemic stroke

Atherosclerosis
Lisa CloonanNatalia S Rost

Abstract

Increasing white matter hyperintensity (WMH) burden is linked to risk of stroke and poor post-stroke outcomes. While the biology of WMH remains ill-defined, several lines of evidence implicate endothelial dysfunction. In this study, we sought to assess the association between metabolic markers of endothelial dysfunction and WMH severity in patients with acute ischemic stroke (AIS). In this retrospective study, consecutive subjects, ≥18 years of age, admitted to our ED with AIS, brain MRI, and blood homocysteine (Hcy) and hemoglobin A1c (HgbA1c) measurements were eligible for this analysis. WMH volume (WMHV) was quantified using a validated semi-automated algorithm and log-transformed for linear regression analyses. There were 809 AIS subjects included (mean age 65.57±14.7, median WMHV 6.25 cm3 (IQR 2.8-13.1)). In univariate analysis, age, female gender, race, ethnicity, systolic blood pressure, history of hypertension, atrial fibrillation, coronary artery disease, prior stroke, and current alcohol and tobacco use (all p<0.05), as well as Hcy (p<0.0001) and HgbA1c levels (p=0.0005) were associated with WMHV. However, only Hcy (β=0.11, p=0.003) and HgbA1c levels (β=0.1, p=0.008) independently predicted WMHV in the multivariate mo...Continue Reading

References

Jan 1, 1992·Journal of Cardiovascular Pharmacology·P VallanceS Moncada
Mar 1, 1997·Stroke; a Journal of Cerebral Circulation·L Pantoni, J H Garcia
Jan 23, 2003·Brain : a Journal of Neurology·Ahamad HassanHugh S Markus
Mar 8, 2003·Stroke; a Journal of Cerebral Circulation·J M WardlawJ Starr
Oct 29, 2003·Circulation·Subodh VermaTodd J Anderson
Jun 5, 2004·Stroke; a Journal of Cerebral Circulation·Lewis H KullerUNKNOWN Cardiovascular Health Study Collaborative Research Group
Jun 26, 2004·Stroke; a Journal of Cerebral Circulation·Tom JeerakathilCharles DeCarli
May 10, 2005·Stroke; a Journal of Cerebral Circulation·Clinton B WrightCharles DeCarli
Jan 6, 2007·Stroke; a Journal of Cerebral Circulation·Karin F HothRonald A Cohen
May 18, 2007·American Journal of Respiratory and Critical Care Medicine·Mary Y YehLou Ann S Brown
Mar 1, 2008·Stroke; a Journal of Cerebral Circulation·Joanna M WardlawMartin S Dennis
Nov 27, 2008·Alcoholism, Clinical and Experimental Research·Michael A CollinsRonald J Korthuis
Aug 28, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·R TopakianH S Markus
Feb 6, 2010·Stroke; a Journal of Cerebral Circulation·Jordi Jimenez-CondeNatalia S Rost
May 4, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Natalia S RostKaren L Furie
Jun 5, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Noboru Toda, Kazuhide Ayajiki
Feb 25, 2011·The Journal of Clinical Endocrinology and Metabolism·Gislaine Vissoky CéMarcello Casaccia Bertoluci
Nov 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Tetsuaki Hirase, Koichi Node
Dec 13, 2012·Stroke; a Journal of Cerebral Circulation·Joanna M WardlawMartin S Dennis
Jan 8, 2013·Reviews in Endocrine & Metabolic Disorders·J David Symons, E Dale Abel
Feb 19, 2013·Reviews in Endocrine & Metabolic Disorders·Etto C EringaVictor W M van Hinsbergh
Feb 28, 2013·International Journal of Molecular Sciences·Shufen ChenHans Worthmann
Apr 17, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Sin Bond LeungZhixiu Lin
Jun 25, 2013·European Journal of Pharmacology·De-shan LiuJi-dong Zhang
Jan 23, 2014·Stroke; a Journal of Cerebral Circulation·Hyung-Min KwonDong-Wha Kang
Jul 9, 2014·Nature Reviews. Nephrology·Tinnakorn ChaiworapongsaRoberto Romero

❮ Previous
Next ❯

Citations

Nov 18, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Minchao LaiYuan Zhang
Apr 20, 2016·Progress in Neurobiology·Yuan WangGuodong Cao
May 31, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Yunis MayasiNils Henninger
Jun 5, 2020·Neurology·Anne-Katrin GieseUNKNOWN International Stroke Genetics Consortium and the MRI-GENIE Investigators
Apr 12, 2019·Frontiers in Neurology·Benedikt M FreyGötz Thomalla
Oct 7, 2018·Journal of Neurology·Xiaodong ChenZhengqi Lu
Dec 3, 2020·International Journal of Nanomedicine·Hyeryeon OhWon Il Choi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Related Papers

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Zachary A CorbinKaren L Furie
Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Cathy R ZhangNatalia S Rost
Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Natalia S RostKaren L Furie
© 2021 Meta ULC. All rights reserved