PMID: 2491996Jan 1, 1989Paper

Metabolic effect of hemipancreatectomy in donors. Preoperative prediction of postoperative oral glucose tolerance

Diabetes
D M KendallJ S Najarian

Abstract

Between November 1977 and January 1987, 55 transplantations of pancreas segments from living donors related to their recipients were performed at the University of Minnesota. A preliminary analysis of metabolic test results in donors tested 1 yr after hemipancreatectomy showed an increase in mean glucose and a decrease in mean insulin values during oral glucose tolerance tests (OGTTs) in 18 donors, a 14% increase in the mean of the mean glucose levels during 24-h metabolic profiles in 12 donors, and a decrease of 45% in the mean 24-h urinary C-peptide excretion in 21 donors. Including the studies performed postdonation, 11 of 31 (35%) donors developed an abnormal OGTT result. In a retrospective analysis, preoperative results of intravenous glucose tolerance tests (IVGTTs) and cortisone-stimulated OGTTs were found to be statistically significant predictors of an abnormal OGTT after hemipancreatectomy. The mean of the 5- to 50-min IVGTT insulin values was the best predictive test. With the cutoff value set at 62 microU/ml, this test result had a sensitivity of 100%, a specificity of 83%, and a positive predictive value of 75% for identifying donors who developed an abnormal OGTT. The sum of the 5- and 10-min IVGTT insulin (cutoff...Continue Reading

Citations

Dec 1, 1995·Diabetes/metabolism Reviews·D E SutherlandA Gruessner
Dec 16, 1993·The New England Journal of Medicine·M A AtkinsonN K Maclaren
Sep 1, 1989·Annals of Surgery·D E SutherlandP Morel
Dec 1, 1994·Scandinavian Journal of Immunology·R CheungH M Dosch
Aug 26, 2014·Diabetes Care·Byron J HoogwerfElizabeth R Seaquist
Aug 31, 1989·The New England Journal of Medicine·P A SingerC E Broelsch
Dec 1, 1993·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·A CokerI Coker

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