PMID: 8943786Sep 1, 1996Paper

Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women

The Journal of Endocrinology
P DiamondF Labrie

Abstract

We have evaluated the effect of dehydroepiandrosterone (DHEA) replacement therapy in 60- to 70-year-old women (n = 15) who received a single daily percutaneous application of a 10% DHEA cream for 12 months. While anthropometric measurements showed no change in body weight, we observed a 9.8% decrease in subcutaneous skinfold thickness at 12 months (P < 0.05). This was confirmed by measurements of midthigh fat and muscle areas by computed tomography where a 3.8% decrease (P < 0.05) in femoral fat and a 3.5% increase (P < 0.05) in femoral muscular areas were observed at 12 months. There was no significant change in abdominal fat measurements but the waist-to-hip ratio was only 0.83 at the onset of treatment. These changes in body fat and muscular mass were associated with a 11% decrease (P < 0.05) in fasting plasma glucose and a 17% decrease (P < 0.05) in fasting insulin levels. Treatment with DHEA had no adverse effect on the lipid or lipoprotein profile. In fact, an overall trend towards a decrease in total cholesterol and its lipoprotein fractions was observed. Plasma triglycerides were not affected. Plasma high-density lipoprotein (HDL) cholesterol decreased by 8% but the ratio HDL/cholesterol was unchanged by DHEA treatment ...Continue Reading

Citations

Aug 7, 2002·Trends in Endocrinology and Metabolism : TEM·Bruno Allolio, Wiebke Arlt
Jul 12, 2002·Journal of the American Geriatrics Society·Maria Clara M PaderoTheodore C Friedman
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·S S Yen
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·E E BaulieuF Forette
Apr 10, 1999·Journal of Clinical Pharmacology·P D KrobothR F Frye
Nov 15, 2007·The Journal of Clinical Endocrinology and Metabolism·Eleanor M GurnellV Krishna K Chatterjee
Jun 23, 2010·The Journal of Clinical Endocrinology and Metabolism·Peter R CassonMarjorie E Dixon
Feb 7, 2007·The Journal of Veterinary Medical Science·Katumasa OokawaHidehiko Yokogoshi

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