Metabolic Effects of a 24-Week Energy-Restricted Intervention Combined with Low or High Dairy Intake in Overweight Women: An NMR-Based Metabolomics Investigation

Nutrients
Hong ZhengHanne Christine Bertram

Abstract

We investigated the effect of a 24-week energy-restricted intervention with low or high dairy intake (LD or HD) on the metabolic profiles of urine, blood and feces in overweight/obese women by NMR spectroscopy combined with ANOVA-simultaneous component analysis (ASCA). A significant effect of dairy intake was found on the urine metabolome. HD intake increased urinary citrate, creatinine and urea excretion, and decreased urinary excretion of trimethylamine-N-oxide (TMAO) and hippurate relative to the LD intake, suggesting that HD intake was associated with alterations in protein catabolism, energy metabolism and gut microbial activity. In addition, a significant time effect on the blood metabolome was attributed to a decrease in blood lipid and lipoprotein levels due to the energy restriction. For the fecal metabolome, a trend for a diet effect was found and a series of metabolites, such as acetate, butyrate, propionate, malonate, cholesterol and glycerol tended to be affected. Overall, even though these effects were not accompanied by a higher weight loss, the present metabolomics data reveal that a high dairy intake is associated with endogenous metabolic effects and effects on gut microbial activity that potentially impact bo...Continue Reading

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Citations

Jul 30, 2017·Molecular Nutrition & Food Research·Ralf KrügerBernhard Watzl
Dec 24, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Åke Nilsson, Rui-Dong Duan
Aug 2, 2019·Molecular Nutrition & Food Research·Sarah O'ConnorIwona Rudkowska
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Apr 9, 2020·Nutrients·Liya AntoChristopher N Blesso
Jan 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Emmanuel Hatzakis
May 21, 2021·Advances in Nutrition·Talha RafiqPhilip Britz-McKibbin

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Methods Mentioned

BETA
nuclear magnetic resonance
X-ray
NMR
PCA

Clinical Trials Mentioned

NCT01199835

Software Mentioned

MATLAB
ASCA
Topspin
zgpr
SAS

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