PMID: 37419Jun 8, 1979

Metabolic effects of a fixed combination (betablocker plus saluretic) in long-term treatment of arterial hypertension (author's transl)

Medizinische Klinik
R P Faupel, R Gotzen


In 23 patients with essential hypertension of stage I and II according to the WHO, the effects of a fixed combination of a beta-receptor-blocker plus saluretic composed of 20 mg of metipranolol (Disorat 20) and 2.5 mg of butizid (Saltucin) = Torrat on blood pressure and important metabolic parameters (glucose, glucose tolerance, cholesterol, triglyceride, uric acid, plasma potassium and whole body potassium) were tested over a 6-month treatment period. blood pressure and pulse rate were significantly reduced; bradycardia (pulse rate less than 60/min) was not observed. The metabolic parameters showed no significant changes during the 6-month treatment period. In no case did the therapy have to be discontinued because of undesirable effects. The investigations show that the combination has a good antihypertensive effect with few side-effects and that it has no influence on important metabolic parameters during long-term therapy.

Related Concepts

Metabolic Process, Cellular
Pulmonary Arterial Hypertension
Plasma Potassium
Physiologic Pulse
Diastolic Blood Pressure
Whole Body

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