PMID: 6110606Feb 1, 1981Paper

Metabolic effects of acute and prolonged growth hormone excess in normal and insulin-deficient man

Diabetologia
P MetcalfeK G Alberti

Abstract

The metabolic effects of acute (4 h) and prolonged (24 h) growth hormone excess at pathophysiological concentrations were studied by growth hormone administration to normal subjects with and without somatostatin induced insulin deficiency. Acute growth hormone excess produced mild hyperinsulinaemia, but blood glucose concentrations were unaltered whereas chronic growth hormone excess caused a small (0.5 mmol/l) but significant rise in overnight-fasting blood glucose concentration together with a similar rise in fasting insulin levels (Mean +/- SEM 9 +/- 1 v 4 +/- 1 mU/l, p less than 0.01). When insulin secretion was suppressed by somatostatin, a hyperglycaemic effect of acute growth hormone excess was unmasked, and the hyperglycaemic effect of chronic growth hormone excess was exaggerated. Acute growth hormone administration without somatostatin had a mild ketogenic action despite stimulated insulin secretion but no change in plasma non-esterified fatty acid or blood glycerol levels was observed. Somatostatin magnified the ketogenic effect of acute growth hormone excess, and unmasked a lipolytic action. Prolonged growth hormone excess had a lipolytic action that was increased by somatostatin, although the ketogenic effect of gr...Continue Reading

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Citations

Apr 1, 1993·Diabetes/metabolism Reviews·S A Amiel
Jan 1, 1984·European Journal of Clinical Pharmacology·A PernetD G Johnston
Jul 5, 2013·Journal of Pharmacokinetics and Pharmacodynamics·Christine AhlströmJohan Gabrielsson
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