Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects: a randomized controlled trial (the RAED2 study).

Diabetes Care
Elisabetta BacchiPaolo Moghetti

Abstract

To assess differences between the effects of aerobic and resistance training on HbA(1c) (primary outcome) and several metabolic risk factors in subjects with type 2 diabetes, and to identify predictors of exercise-induced metabolic improvement. Type 2 diabetic patients (n = 40) were randomly assigned to aerobic training or resistance training. Before and after 4 months of intervention, metabolic phenotypes (including HbA(1c), glucose clamp-measured insulin sensitivity, and oral glucose tolerance test-assessed β-cell function), body composition by dual-energy X-ray absorptiometry, visceral (VAT) and subcutaneous (SAT) adipose tissue by magnetic resonance imaging, cardiorespiratory fitness, and muscular strength were measured. After training, increase in peak oxygen consumption (V(O(2peak))) was greater in the aerobic group (time-by-group interaction P = 0.045), whereas increase in strength was greater in the resistance group (time-by-group interaction P < 0.0001). HbA(1c) was similarly reduced in both groups (-0.40% [95% CI -0.61 to -0.18] vs. -0.35% [-0.59 to -0.10], respectively). Total and truncal fat, VAT, and SAT were also similarly reduced in both groups, whereas insulin sensitivity and lean limb mass were similarly increa...Continue Reading

References

Sep 18, 2001·JAMA : the Journal of the American Medical Association·N G BouléR J Sigal
Jan 17, 2003·Obesity Research·Wei ShenSteven B Heymsfield
Apr 13, 2004·Medicine and Science in Sports and Exercise·Pedro Curi Hallal, Cesar Gomes Victora
Jul 15, 2004·American Journal of Physiology. Endocrinology and Metabolism·Flemming DelaHenrik Galbo
Mar 17, 2005·The Journal of Clinical Endocrinology and Metabolism·Yoshifumi TamuraRyuzo Kawamori
Apr 28, 2005·Diabetes Care·UNKNOWN Workgroup on Hypoglycemia, American Diabetes Association
Apr 25, 2006·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S J Kay, M A Fiatarone Singh
Jul 21, 2006·The Cochrane Database of Systematic Reviews·D E ThomasG A Naughton
Oct 19, 2010·Diabetologia·J LaroseUNKNOWN Diabetes Aerobic and Resistance Exercise (DARE) trial investigators
Nov 26, 2010·JAMA : the Journal of the American Medical Association·Timothy S ChurchConrad P Earnest
Jan 14, 2011·Diabetes Care·UNKNOWN American Diabetes Association

❮ Previous
Next ❯

Citations

May 10, 2013·Internal and Emergency Medicine·Luca MontesiGiulio Marchesini
Jan 24, 2014·BioMed Research International·Barbara Strasser, Dominik Pesta
May 10, 2013·European Journal of Applied Physiology·Borja SañudoArturo Figueroa
Sep 21, 2013·Medicine and Science in Sports and Exercise·Christian K RobertsJohn P Thyfault
Feb 26, 2016·European Journal of Radiology·Thomas BaumDimitrios C Karampinos
Jul 3, 2013·Metabolism: Clinical and Experimental·Katharine E HallC W James Melling
Jan 30, 2016·Oxidative Medicine and Cellular Longevity·Nada Sallam, Ismail Laher
Nov 22, 2012·Annals of the New York Academy of Sciences·Barbara Strasser
Mar 19, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisabetta BacchiPaolo Moghetti
Oct 17, 2013·Diabetes/metabolism Research and Reviews·S MannA Jimenez
Apr 5, 2016·Digestive Diseases and Sciences·Jonathan A AfricaJeffrey B Schwimmer
Jun 30, 2016·Diabetes & Metabolic Syndrome·Shalini Verma, M Ejaz Hussain
Oct 1, 2013·International Journal of Endocrinology·Elisabetta Bacchi, Paolo Moghetti
Oct 28, 2016·Psychiatry Research·Joseph FirthBrendon Stubbs
Aug 18, 2017·Medicine and Science in Sports and Exercise·Kim A GaffneyDavid S Rowlands
Jul 4, 2015·Circulation Research·Carl J LavieSteven N Blair
Jan 4, 2019·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Jan 10, 2019·International Journal of Environmental Research and Public Health·Yubo LiuMallikarjuna Korivi
Jul 19, 2018·American Journal of Physical Medicine & Rehabilitation·Fuyuan LiaoYih-Kuen Jan
Nov 18, 2018·The Journal of Clinical Endocrinology and Metabolism·Debora OliosoPaolo Moghetti
Mar 15, 2019·Clinical and Experimental Hypertension : CHE·Carlos Leonardo Figueiredo MachadoRonei Silveira Pinto
Jun 28, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mats I NilssonJames D Fluckey
Feb 6, 2020·Experimental Physiology·Michelle CurranParth Narendran
Jul 7, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Naoki HoriiMotoyuki Iemitsu
Feb 12, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisabetta BacchiPaolo Moghetti
Mar 2, 2019·Journal of Cardiovascular Translational Research·Shunchang LiIsmail Laher

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

MetaDieta
STATA

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.

Biomechanics

Biomechanics examines the generation of internal forces within the body and investigates the effects and control of forces that act on or are produced on tissues. Here are the latest discoveries.