Metabolic effects of darunavir/ritonavir versus atazanavir/ritonavir in treatment-naive, HIV type 1-infected subjects over 48 weeks.

AIDS Research and Human Retroviruses
Judith A AbergGuy De La Rosa

Abstract

We assessed metabolic changes for darunavir/ritonavir (DRV/r) once daily (qd) versus atazanavir/ritonavir (ATV/r) qd with fixed-dose tenofovir/emtricitabine. This was a phase 4, multicenter, open-label, randomized exploratory study. Treatment-naive, HIV-1-infected adults received DRV/r 800/100 mg qd or ATV/r 300/100 mg qd, both with emtricitabine/tenofovir 200/300 mg qd. Primary end point: change in triglyceride levels from baseline to week 12. Secondary end points: week 12 and week 48 changes in lipid parameters, insulin sensitivity, inflammatory/coagulation/bacterial translocation biomarkers, viral load, CD4(+) cell count, and week 48 changes in adipose tissue distribution and subjects' perceptions of body changes. In the DRV/r arm, 32/34 and 29/34 subjects completed weeks 12 and 48, respectively; in the ATV/r arm, 30/31 and 25/31 subjects completed weeks 12 and 48, respectively. Small changes in lipid parameters from baseline to weeks 12 and 48 were observed in both arms. Differences were noted between arms in mean changes in total cholesterol (DRV/r, 20.3 mg/dl; ATV/r, 4.6 mg/dl) and apolipoprotein A1 (DRV/r, 10.7 mg/dl; ATV/r, -0.7 mg/dl) at week 12. At week 48, no clinically relevant differences between arms were noted fo...Continue Reading

References

Feb 18, 1998·The Journal of Infectious Diseases·J AngelD Bass
Mar 5, 1999·The Journal of the Association of Nurses in AIDS Care : JANAC·N H MelroeJ Huebsch
Jan 28, 2003·Progress in Lipid Research·David Y Hui
Jun 12, 2003·JAMA : the Journal of the American Medical Association·Sharon A RiddlerLawrence A Kingsley
Apr 20, 2004·AIDS·Grace A LeeCarl Grunfeld
Feb 8, 2005·Journal of General Internal Medicine·William E CunninghamRon D Hays
Aug 17, 2006·AIDS Research and Human Retroviruses·Philip J NorrisMichael P Busch
Nov 23, 2006·Nature Medicine·Jason M BrenchleyDaniel C Douek
Apr 27, 2007·The New England Journal of Medicine·UNKNOWN DAD Study GroupJens D Lundgren
Jun 28, 2007·Annals of Clinical Biochemistry·Anwar BoraiGordon A A Ferns
Mar 5, 2008·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Anthony J BustiDana S Hardin
Jun 12, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sharon A RiddlerUNKNOWN Multicenter AIDS Cohort Study
Jul 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael P DubéKieren J Mather
Nov 14, 2008·AIDS·Andrew N PhillipsJens D Lundgren
May 7, 2009·AIDS·Richard H HaubrichUNKNOWN AIDS Clinical Trials Group (ACTG) A5142 Study Team
Dec 18, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I Marion de Boer-van der KolkPythia T Nieuwkerk
Dec 22, 2009·AIDS Care·Jamie Stephen KellyLucy Serpell
Mar 2, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ravinder Kaur SachdevaMeera Sharma
May 8, 2010·The Journal of Infectious Diseases·Jacqueline NeuhausJames D Neaton
May 27, 2010·AIDS·Carl GrunfeldUNKNOWN Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM)

❮ Previous
Next ❯

Citations

May 24, 2013·Reviews in Endocrine & Metabolic Disorders·Ovidiu GalescuSvetlana Ten
May 25, 2013·Clinical Pharmacokinetics·Benoit ChauvinAnne-Marie Taburet
Sep 5, 2013·Drugs·Giovanni GuaraldiAntonella Santoro
Oct 26, 2013·The Lancet Infectious Diseases·Jordan E Lake, Judith S Currier
Feb 14, 2014·European Journal of Endocrinology·Suman Srinivasa, Steven K Grinspoon
Aug 30, 2014·Endocrinology and Metabolism Clinics of North America·Theodoros Kelesidis, Judith S Currier
Jun 22, 2014·The Journal of Antimicrobial Chemotherapy·Thomas N KakudaRichard M W Hoetelmans
Jan 23, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Grace A McComseyTodd T Brown
Jan 15, 2014·HIV Medicine·E MartinezUNKNOWN ATADAR Study Group
Mar 15, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ighovwerha OfotokunUNKNOWN AIDS Clinical Trials Group (ACTG) A5257 Team
Mar 30, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Stephen S JohnstonJonathan Uy
May 6, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Bret J RudyUNKNOWN Adolescent Trials Network for HIVAIDS Interventions
Jan 9, 2015·Infectious Diseases and Therapy·Corinne Isnard Bagnis, Hans-Jürgen Stellbrink
Nov 13, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Esteban MartinezUNKNOWN ATADAR Study Group
Jan 10, 2018·Journal of Endocrinological Investigation·F S MirzaL Chirch
Aug 30, 2018·PloS One·Janine M TrevillyanUNKNOWN ALTAIR Study Group
Apr 14, 2015·The Open AIDS Journal·Daniel B ChastainKayla R Stover
Mar 19, 2014·AIDS·Kristine Mace ErlandsonGrace A McComsey
Apr 13, 2012·The Annals of Pharmacotherapy·Kristina E E RokasSharon B Weissman
Aug 20, 2020·AIDS Care·David E WallaceUNKNOWN DC Cohort Executive Committee
Apr 27, 2017·Expert Review of Anti-infective Therapy·Francisco Antunes
Aug 20, 2016·Current HIV/AIDS Reports·Amanda L Willig, Edgar Turner Overton
Aug 27, 2016·Current HIV/AIDS Reports·Emma Kaplan-LewisMikyung Lee
Apr 13, 2017·BMC Infectious Diseases·Tony AntoniouUNKNOWN Canadian Observational Cohort (CANOC) collaboration

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry

Clinical Trials Mentioned

NCT00811954

Software Mentioned

METABOLIK
ARTEMIS

Related Concepts

Related Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.