Metabolic effects of eradicating breath methane using antibiotics in prediabetic subjects with obesity

Obesity
R MathurMark Pimentel

Abstract

Methanogens colonizing the human gut produce methane and influence host metabolism. This study examined metabolic parameters in methane-producing subjects before and after antibiotic treatment. Eleven prediabetic methane-positive subjects (9F, 2M) with obesity (BMI 35.17 ± 7.71 kg/m(2) ) aged 47 ± 9 years were recruited. Subjects underwent breath testing, symptom questionnaire, oral glucose tolerance test (OGTT), lipid profile, and stool Methanobrevibacter smithii levels, gastric transit, and energy utilization analyses. After a 10-day antibiotic therapy (neomycin 500 mg bid/rifaximin 550 mg tid), all testing was repeated. Baseline stool M. smithii levels correlated with breath methane (R = 0.7, P = 0.05). Eight subjects (73%) eradicated breath methane and showed reduced stool M. smithii (P = 0.16). After therapy, methane-eradicated subjects showed significant improvements in low-density lipoprotein (LDL) (P = 0.028), total cholesterol (P = 0.01), and insulin levels on OGTT (P = 0.05 at 120 minutes), lower blood glucose levels on OGTT (P = 0.054 at 90 minutes), significant reductions in bloating (P = 0.018) and straining (P = 0.059), and a trend toward lower stool dry weight. No changes were detected in gastric emptying time or...Continue Reading

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Citations

Jul 7, 2016·Obesity Research & Clinical Practice·Ruchi MathurMark Pimentel
Apr 17, 2018·Diabetes/metabolism Research and Reviews·Sandra Aparecida Dos ReisJosefina Bressan
Jul 15, 2020·Journal of Breath Research·Juliana SicchieriRicardo Brandt de Oliveira
Dec 1, 2017·Endocrinology, Diabetes & Metabolism·Rose LaverdureJeffrey Gagnon
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Tahli Singer-EnglarRuchi Mathur
Jun 9, 2018·United European Gastroenterology Journal·Clive H Wilder-SmithAsbjørn M Drewes
Feb 23, 2018·Frontiers in Pharmacology·Zhi-Jun DengQing-Ping Zeng
Nov 29, 2020·Digestive Diseases and Sciences·Levi TeigenAlexander Khoruts
Mar 9, 2021·Frontiers in Cellular and Infection Microbiology·Li WangQiuhe Ji

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