Metabolic effects of hemodialysis with and without glucose in the dialysate

Kidney International
Y BouffardJ Motin


This study was conducted in eight acute renal failure patients undergoing mechanical ventilation to test if the addition of glucose in the dialysate prevents metabolic and hormonal changes induced by hemodialysis. Hemodialysis was performed with a bicarbonate dialysate, a polyacrilonitrile membrane and a continuous heparinization. Two four-hour hemodialysis sessions were performed in each patient: one without glucose (GFD) and one with glucose (GD) in the dialysate at a concentration close to each patient's initial plasma glucose concentration. Oxygen consumption and carbon dioxide elimination, glucose insulin, aceto-acetate and free fatty acids were measured before, during and after the sessions. Oxygen consumption and carbon dioxide elimination were measured with a system using a mass spectrometer. Hemodynamic state and temperature remained constant. Before hemodialysis, respiratory quotient (RQ) values were the same in both groups. There was no change in RQ during GD. There was a decrease in RQ during GFD. Glucose and insulin concentrations decreased during GFD and remained unchanged during GD. Aceto-acetate concentration remained constant under both conditions. Free fatty acids concentration increased to the same extent dur...Continue Reading


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Mar 28, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Maren Sangill, Erling B Pedersen
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Jan 13, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Daniel SchneditzMark Hoehlein

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