Metabolic effects of hemodialysis with and without glucose in the dialysate

Kidney International
Y BouffardJ Motin

Abstract

This study was conducted in eight acute renal failure patients undergoing mechanical ventilation to test if the addition of glucose in the dialysate prevents metabolic and hormonal changes induced by hemodialysis. Hemodialysis was performed with a bicarbonate dialysate, a polyacrilonitrile membrane and a continuous heparinization. Two four-hour hemodialysis sessions were performed in each patient: one without glucose (GFD) and one with glucose (GD) in the dialysate at a concentration close to each patient's initial plasma glucose concentration. Oxygen consumption and carbon dioxide elimination, glucose insulin, aceto-acetate and free fatty acids were measured before, during and after the sessions. Oxygen consumption and carbon dioxide elimination were measured with a system using a mass spectrometer. Hemodynamic state and temperature remained constant. Before hemodialysis, respiratory quotient (RQ) values were the same in both groups. There was no change in RQ during GD. There was a decrease in RQ during GFD. Glucose and insulin concentrations decreased during GFD and remained unchanged during GD. Aceto-acetate concentration remained constant under both conditions. Free fatty acids concentration increased to the same extent dur...Continue Reading

References

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Citations

Mar 28, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Maren Sangill, Erling B Pedersen
Aug 27, 2011·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Roza Czabak-GarbaczBarbara Obermayer-Pietsch
Feb 28, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Noël J M Cano, Xavier M Leverve
Feb 20, 2010·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Daniel SchneditzKarl Thomaseth
Jun 27, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cheng XueZhi-Guo Mao
Mar 6, 2015·The Cochrane Database of Systematic Reviews·Jin Hui TianTian Xi Liu
Jan 13, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Daniel SchneditzMark Hoehlein

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