Metabolic Effects of Late Dinner in Healthy Volunteers-A Randomized Crossover Clinical Trial.

The Journal of Clinical Endocrinology and Metabolism
Chenjuan GuJonathan C Jun

Abstract

Consuming calories later in the day is associated with obesity and metabolic syndrome. We hypothesized that eating a late dinner alters substrate metabolism during sleep in a manner that promotes obesity. The objective of this work is to examine the impact of late dinner on nocturnal metabolism in healthy volunteers. This is a randomized crossover trial of late dinner (LD, 22:00) vs routine dinner (RD, 18:00), with a fixed sleep period (23:00-07:00) in a laboratory setting. Participants comprised 20 healthy volunteers (10 male, 10 female), age 26.0 ± 0.6 years, body mass index 23.2 ± 0.7 kg/m2, accustomed to a bedtime between 22:00 and 01:00. An isocaloric macronutrient diet was administered on both visits. Dinner (35% daily kcal, 50% carbohydrate, 35% fat) with an oral lipid tracer ([2H31] palmitate, 15 mg/kg) was given at 18:00 with RD and 22:00 with LD. Measurements included nocturnal and next-morning hourly plasma glucose, insulin, triglycerides, free fatty acids (FFAs), cortisol, dietary fatty acid oxidation, and overnight polysomnography. LD caused a 4-hour shift in the postprandial period, overlapping with the sleep phase. Independent of this shift, the postprandial period following LD was characterized by higher glucose...Continue Reading

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Citations

Nov 4, 2020·The Journal of Clinical Endocrinology and Metabolism·Steven K Malin
Jan 12, 2021·Stress and Health : Journal of the International Society for the Investigation of Stress·Cihat UçarSedat Yıldız
Dec 2, 2020·Current Biology : CB·Kelly C AllisonNamni Goel
Jan 15, 2021·Archives of Endocrinology and Metabolism·Bruno Halpern, Thiago Bosco Mendes
Feb 2, 2021·Ergonomics·Jamie L TaitLuana C Main
Apr 23, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Lijun ZhaoLeonie K Heilbronn
Aug 31, 2021·Frontiers in Endocrinology·Bettina SchuppeliusOlga Pivovarova-Ramich
Sep 24, 2021·The British Journal of Nutrition·Tomoyuki Kawada
Jan 18, 2022·The Journal of Physiology·Harry A Smith, James A Betts

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