Metabolic effects of long-term treatments with nifedipine-retard and captopril in young hypertensive patients

American Journal of Hypertension
Kazuko MasuoM L Tuck

Abstract

The objective of this study was to clarify potential differences in the metabolism of glucose and lipids in a long-term treatment (for 5 years) for hypertension among nifedipine-retard and captopril in young, nonobese hypertensive men (HT). In 78 previously untreated HT who were given nifedipine-retard and in 81 HT given captopril, blood pressure (BP), pulse rate, blood glucose, and plasma insulin levels were measured every 30 min for 2 h after 75 g oral glucose ingestion, every year for 5 years. Twenty-six age- and body mass index (BMI)-matched normotensive men (NT) were measured for the same variables for 5 years. They were also measured for total cholesterol, triglyceride levels, and lipids fractions after an overnight fast, every year for 5 years without any kinds of lipid lowering agents. At 1 year after treatment with nifedipine-retard or captopril, BP decreased significantly, and the reductions in BP did not differ between HT treated with nifedipine-retard and captopril. In the entry period, fasting insulin (P < .05), the area under the curve (AUC) of insulin (P < .01), AUC of blood glucose (P < .05) after 75 g oral glucose ingestion, fasting total cholesterol (P < .05), and triglyceride levels (P < .05) in HT were signi...Continue Reading

Citations

May 20, 2000·Hypertension·K MasuoM L Tuck
Aug 21, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·K MasuoM L Tuck
Nov 23, 2011·Expert Review of Cardiovascular Therapy·Giuseppe Derosa, Pamela Maffioli
Mar 31, 2018·Expert Opinion on Pharmacotherapy·Revathy CarnagarinMarkus P Schlaich

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