Metabolic Effects of Testosterone Therapy in Men with Type 2 Diabetes and Metabolic Syndrome

Sexual Medicine Reviews
Geoffrey Hackett

Abstract

Up to 40% of men with type 2 diabetes (T2DM) and metabolic syndrome (MetS) have hypogonadotrophic hypogonadism (HH). Men with HH are at increased risk of cardiovascular (CV) and all-cause mortality, as well as of the development of incident T2DM. To review the current literature on the metabolic effects of testosterone therapy (TTh) in men with T2DM and MetS. We searched MEDLINE, Embase, and Cochrane Reviews for articles on T2DM, HH, testosterone deficiency, and CV and all-cause mortality published between May 2005 and July 2018, yielding 1817 articles, including 54 clinical trials and 32 randomized controlled trials (RCTs). The main outcomes were glycemic control, insulin resistance, lipid profile, and metabolic markers associated with increased CV risk. RCTs of TTh suggest significant benefits for sexual function, quality of life, glycemic control, insulin sensitivity, anemia, bone density, and fat and lean muscle mass that might be expected to translate into reduced long-term morbidity and mortality. Several longitudinal and observational studies suggest long-term sustained improvements in metabolic parameters and a trend toward reduced CV and all-cause mortality, especially in men at increased CV risk, such as those with T2...Continue Reading

Citations

Oct 17, 2019·European Endocrinology·Cornelius J FernandezJoseph M Pappachan
Dec 11, 2019·Journal of Cardiovascular Translational Research·Margarida LorigoElisa Cairrao
Dec 13, 2019·Case Reports in Endocrinology·Analía Verónica YamaguchiPablo Knoblovits
Oct 23, 2020·International Journal of Molecular Sciences·Xavier Remesar, Marià Alemany
Jan 21, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Shang-Rong ZhongChun-Cheng Liao
May 14, 2021·The Journal of Clinical Endocrinology and Metabolism·Xiaohui LiGuang Wang

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