Metabolic effects of the consumption of Areca catechu

Addiction Biology
B J Boucher, N Mannan

Abstract

Betel nut (Areca catechu) is chewed regularly by at least 10% of the world population, imported by immigrant users wherever they settle, and is the fourth most widely used addictive substance. It is thought, by users, to soothe the digestion and to be a stimulant and its use has a major role in social situations. Specific arecal alkaloids act as competitive inhibitors of GABA receptors and have widespread effects in the body, including actions on the brain, cardiovascular system, lungs, gut and pancreas. Nitrosated derivatives of arecal alkaloids, proven carcinogens inducing tumours throughout the upper gut and foregut derivatives in animals, are also associated with increased tumour risks in man. These nitrosated compounds are also diabetogenic in CD1 mice, producing a type 2 diabetes with obesity. Increased central obesity is found in association with betel usage in man as well as increases in circulating markers of inflammatory and cardiovascular damage. The effects of chronic betel usage in man are at least as diverse as those of smoking and the habit increases the risks of ill health.

References

May 1, 1976·Pharmacology, Biochemistry, and Behavior·M E Stricherz, P Pratt
May 9, 1992·Lancet·R F TaylorN C Barnes
Feb 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A B SarmaA Mukherjee
Mar 1, 1991·Indian Journal of Pediatrics·N H Antia
Feb 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P R MurtiJ J Pindborg
May 19, 1990·BMJ : British Medical Journal·G G DahlquistS G Wall
Jan 1, 1989·Movement Disorders : Official Journal of the Movement Disorder Society·M Deahl
Jan 1, 1985·Journal of Cancer Research and Clinical Oncology·H GeyerB Hornberger
Jan 1, 1980·The American Journal of Clinical Nutrition·M S ReddyH K Chuttani
Oct 1, 1995·Comparative Biochemistry and Physiology. Part A, Physiology·N J TillakaratneK M Gibson
Dec 1, 1993·Kidney International·D SorbiL Arbeit
Jan 1, 1993·Cardiovascular Research·A L Tucker, J Linden
Feb 3, 1998·Journal of the American Academy of Dermatology·S A Norton
Feb 24, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·H M MatherJ H Fuller
Apr 9, 1998·Journal of Ethnopharmacology·P PeungvichaS Kadota
Aug 26, 1998·Journal of the American College of Cardiology·H KaiT Imaizumi
Dec 16, 1998·Lancet·O A ObeidB J Boucher
Feb 17, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S Panda, A Kar
Mar 31, 2000·European Journal of Gastroenterology & Hepatology·S DominguezP Ruszniewski
Oct 12, 2000·The British Journal of Psychiatry : the Journal of Mental Science·R J SullivanK Nero

❮ Previous
Next ❯

Citations

Oct 2, 2012·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Sunil Srichand NichlaniArunprabhu Ganeshan
Aug 24, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·W-C ChangT-Y Tai
Jan 19, 2012·International Journal of Epidemiology·Julia E HeckYu Chen
Oct 26, 2012·BMC Cardiovascular Disorders·Mohammad Perwaiz IqbalIqbal Azam
Nov 4, 2006·BMC Public Health·Chin-Feng LinYing-Chin Ko
Jul 4, 2012·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Sidramesh Shivanand MuttagiPrashant Pawar
Aug 13, 2014·TheScientificWorldJournal·Ping-Ho ChenBin Huang
Feb 20, 2014·International Journal of Epidemiology·Tyler R McClintockYu Chen
Jan 12, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chung-Hung TsaiYu-Chao Chang
Aug 24, 2011·Nordic Journal of Psychiatry·Maurizio Coppola, Raffaella Mondola
Aug 31, 2010·Journal of Zhejiang University. Science. B·Li-Na ZhangQin-qing Hu
May 23, 2015·International Journal of Food Sciences and Nutrition·Mahendra RaiAvinash P Ingle
Aug 29, 2012·Dermato-endocrinology·Barbara J Boucher
Nov 16, 2010·Cardiology Research and Practice·Chin-Hsiao Tseng
Jul 17, 2014·Food Additives & Contaminants. Part B, Surveillance·Muhammad Asif AsgharZuzzer Ali Shamsuddin
Jul 30, 2014·BMC Public Health·Fu-Li ChenMin-Chien Tsai
Nov 3, 2011·Chest·Michael LevineSteven C Curry
Oct 31, 2006·Oral Oncology·Tsai Chung-HungChang Yu-Chao
Apr 14, 2007·Journal of Immigrant and Minority Health·Alejandra Núñez-de la MoraGillian R Bentley
Jun 26, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Fu-Mei ChungYau-Jiunn Lee
Mar 1, 2008·Journal of Psychopharmacology·S-S Chiou, C-D Kuo
Aug 7, 2010·Scandinavian Journal of Public Health·Fawad JavedKhalid Almas
Jul 14, 2017·Archives of Physiology and Biochemistry·Indraneel SahaB R Maiti
Dec 29, 2017·Oral Diseases·M L GiovannoniE Chimenos-Küstner
Dec 7, 2017·Frontiers in Psychiatry·Xiaojun HuangZhening Liu
Jun 30, 2018·Perspectives in Public Health·Shelly Arora, Christopher Squier
Apr 24, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jianhong ZhouJie Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved