Metabolic engineering for amino-, oligo-, and polysugar production in microbes

Applied Microbiology and Biotechnology
Gazi Sakir HossainLong Liu

Abstract

Amino-, oligo-, and polysugars are important for both medicinal and industrial applications. Microbial processes used in production of such sugars are not only carbon-intensive and energy-demanding processes but also have other distinct disadvantages such as low productivity, low yields, and by-product contamination. Therefore, metabolic engineering has emerged as an effective tool for developing engineered strains to deliver production strategies for many valuable sugars, which were previously difficult to manufacture by other means, in necessary amounts to support their applications. In this review, the recent strategies used for metabolic engineering are summarized and future prospects of this technique are discussed. We hope that this review will contribute to the development of functional and high-value sugar production by metabolic engineering strategies.

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Citations

Jan 18, 2018·The Journal of Biological Chemistry·Lisa A AndersonKristala L J Prather
Mar 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chen ZouYan Xu
Jun 27, 2019·Journal of Proteome Research·Caixiang LiuHuiru Tang

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