Metabolic Engineering for Improved Fermentation of L-Arabinose

Journal of Microbiology and Biotechnology
Suji YeSoo Rin Kim

Abstract

L-Arabinose, a five carbon sugar, has not been considered as an important bioresource because most studies have focused on D-xylose, another type of five-carbon sugar that is prevalent as a monomeric structure of hemicellulose. In fact, L-arabinose is also an important monomer of hemicellulose, but its content is much more significant in pectin (3-22%, g/g pectin), which is considered an alternative biomass due to its low lignin content and mass production as juiceprocessing waste. This review presents native and engineered microorganisms that can ferment L-arabinose. Saccharomyces cerevisiae is highlighted as the most preferred engineering host for expressing a heterologous arabinose pathway for producing ethanol. Because metabolic engineering efforts have been limited so far, with this review as momentum, more attention to research is needed on the fermentation of L-arabinose as well as the utilization of pectin-rich biomass.

Citations

Sep 11, 2019·Journal of Industrial Microbiology & Biotechnology·Suji YeSoo Rin Kim
Dec 15, 2020·FEMS Microbiology Reviews·Justyna Ruchala, Andriy A Sibirny
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jinjin PengYongjun Wei
Aug 4, 2021·Nature Reviews. Microbiology·José Montaño LópezJosé L Avalos
Jul 7, 2021·Journal of Microbiology and Biotechnology·Yi WangZongjun Cui
Sep 10, 2021·Microbial Cell Factories·Sami HavukainenChristopher P Landowski

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