Metabolic engineering for the production of isoprene and isopentenol by Escherichia coli

Applied Microbiology and Biotechnology
Meijie LiHaibo Zhang

Abstract

The biotechnological production of isoprene and isopentenol has recently been studied. Isoprene, which is currently made mainly from petroleum, is an important platform chemical for synthesizing pesticides, medicines, oil additives, fragrances, and more and is especially important in the rubber production industry. Isopentenols, which have better combustion properties than well-known biofuels (ethanol), have recently received more attention. Supplies of petroleum, the conventional source of isoprene and isopentenols, are unsustainable, and chemical synthesis processes could cause serious environmental problems. As an alternative, the biosynthesis of isoprene and isopentenols in cell factories is more sustainable and environmentally friendly. With a number of advantages over other microorganisms, Escherichia coli is considered to be a powerful workhorse organism for producing these compounds. This review will highlight the recent advances in metabolic engineering for isoprene and isopentenol production, especially using E. coli cell factories.

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Citations

May 28, 2019·Applied Microbiology and Biotechnology·Sandra Moser, Harald Pichler
Dec 20, 2019·Organic & Biomolecular Chemistry·James McCloryMeilan Huang
Jul 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhaobao WangJianming Yang
Oct 25, 2020·Journal of Applied Microbiology·H PramastyaW J Quax
Sep 4, 2020·Biotechnology Advances·Yuyao RenYongjin J Zhou
May 4, 2021·Medicinal Research Reviews·Zhimin HuLuqi Huang
Nov 19, 2020·Journal of Agricultural and Food Chemistry·Meijie LiJianming Yang

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Datasets Mentioned

BETA
CAC35696.1
AB198180.1
ADV58934.1
ACD70404.1
BAF02831.1

Methods Mentioned

BETA
environmental stresses
glycosylation

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