PMID: 8939631Oct 1, 1996Paper

Metabolic engineering of polyketide biosynthesis

Current Opinion in Biotechnology
C L Hershberger

Abstract

Three elements came together during the past year to provide the opportunity to generate new polyketides. The first was the availability of cloned genes for several metabolic pathways; the second was a genetically defined host strain able to support the production of polyketides; and the third was the ability to modify specific genes and recombine genes from different pathways using recombinant DNA technology. These tools culminated in the rational design of new molecules and the biosynthesis of large numbers of new molecules using combinatorial biology.

Citations

Oct 12, 2000·Angewandte Chemie·J Rohr
Feb 14, 2006·FEMS Microbiology Reviews·Jose L Adrio, Arnold L Demain
Apr 18, 1998·Applied and Environmental Microbiology·N B FitzgeraldT J Vanden Boom
Sep 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·A A Brakhage

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