PMID: 8879408Oct 1, 1996Paper

Metabolic engineering of sugar catabolism in lactic acid bacteria

Antonie van Leeuwenhoek
Willem M de Vos


Lactic acid bacteria are characterized by a relatively simple sugar fermentation pathway that, by definition, results in the formation of lactic acid. The extensive knowledge of traditional pathways and the accumulating genetic information on these and novel ones, allows for the rerouting of metabolic processes in lactic acid bacteria by physiological approaches, genetic methods, or a combination of these two. This review will discuss past and present examples and future possibilities of metabolic engineering of lactic acid bacteria for the production of important compounds, including lactic and other acids, flavor compounds, and exopolysaccharides.


Mar 1, 1978·Journal of Bacteriology·R C FaheyM B Worsham
Sep 1, 1990·FEMS Microbiology Reviews·J Cerning
Oct 20, 1991·Journal of Molecular Biology·T StehleG E Schulz
Sep 1, 1990·FEMS Microbiology Reviews·J London
Jun 1, 1989·FEMS Microbiology Reviews·J Reizer
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A J DriessenW N Konings
Oct 1, 1985·Applied and Environmental Microbiology·R HutkinsL L McKay
Feb 1, 1974·Journal of Dairy Science·L L McKay, K A Baldwin
Jan 1, 1972·Advances in Microbial Physiology·I W Sutherland
Mar 15, 1980·Lancet·H de Waard
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R OttoW N Konings
Jun 1, 1981·Journal of Bacteriology·F S Archibald, I Fridovich
Jan 1, 1984·Journal of Bacteriology·V L Crow, T D Thomas
Aug 30, 1995·Molecular & General Genetics : MGG·J E GermondB Mollet
Nov 10, 1995·The Journal of Biological Chemistry·Oscar P KuipersWillem M de Vos


Feb 6, 2004·Trends in Biotechnology·Willem M de Vos, J Hugenholtz
Feb 26, 2000·Enzyme and Microbial Technology·K Hofvendahl, B Hahn-Hägerdal
Mar 17, 2001·International Journal of Food Microbiology·A N HassanS I Shalabi
Mar 17, 2001·International Journal of Food Microbiology·M L StecchiniM Munari
Sep 17, 1999·International Journal of Food Microbiology·E Caplice, G F Fitzgerald
Jul 27, 2002·Journal of Biotechnology·Michiel KleerebezemJ Hugenholtz
Jan 3, 2001·Applied and Environmental Microbiology·A RamosHelena Santos
May 26, 2001·Applied and Environmental Microbiology·N B JensenJ Villadsen
Feb 7, 2003·Applied and Environmental Microbiology·Ingeborg C BoelsWillem M de Vos
Feb 7, 2003·Applied and Environmental Microbiology·Mario VarcamontiMaurilio De Felice
Nov 5, 2005·Applied and Environmental Microbiology·Christophe GittonMichel-Yves Mistou
Jun 29, 2005·BMC Microbiology·Ana Paula OliveiraJochen Förster
Feb 9, 2013·Critical Reviews in Food Science and Nutrition·V K Shiby, H N Mishra
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Maristela Boaceff CirauloLuiz R Nunes
Apr 14, 1999·Molecular Microbiology·D O GostickJ R Guest
Jun 15, 2007·Critical Reviews in Microbiology·Zijun Xiao, Ping Xu
Oct 13, 2014·Journal of Dairy Science·Y F ChenH P Zhang
May 25, 2016·Food Microbiology·Christelle F IskandarAnne-Marie Revol-Junelles
Jul 27, 2011·PloS One·Roman K GóreckiJacek K Bardowski

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.