Metabolic evidence for remote inhibition in epilepsies with continuous spike-waves during sleep

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X De TiègePatrick Van Bogaert

Abstract

Epileptic syndromes with continuous spikes and waves during sleep (CSWS) are characterized by an acute phase with the emergence of psychomotor deficits and CSWS activity and by a recovery phase in which patients' clinical condition improves together with the remission of CSWS activity. The pathophysiological mechanisms of how CSWS activity induces psychomotor regression are still poorly understood. PET studies using [18F]-fluorodeoxyglucose (FDG) were performed in 9 children during acute and recovery phases of CSWS. PET data were analyzed at individual and group levels using statistical parametric mapping via subtractive, exclusive masking and variance analyses. Pathophysiological interaction analyses were conducted to determine the evolution of changes in effective connectivity between hypermetabolic and hypometabolic brain areas. At the individual level, CSWS recovery was characterized by a complete or almost complete regression of both hypermetabolic and hypometabolic abnormalities observed during the acute phase. Similar evolution was observed at the group level. Indeed, altered effective connectivity between focal hypermetabolism (centro-parietal regions and right fusiform gyrus) and widespread hypometabolism (prefrontal a...Continue Reading

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Citations

May 15, 2013·Current Neurology and Neuroscience Reports·Pasquale Striano, Giuseppe Capovilla
Aug 18, 2009·Epilepsia·Carlo A TassinariGuido Rubboli
Aug 18, 2009·Epilepsia·Philippe F PaquierPatrick Van Bogaert
Aug 18, 2009·Epilepsia·Stefano SeriAntonella Cerquiglini
Jan 8, 2013·EJNMMI Research·Frederique ArchambaudCatherine Chiron
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Dec 30, 2014·Epilepsy & Behavior : E&B·Sophie GalerPatrick Van Bogaert
Aug 31, 2013·Epilepsy Research and Treatment·Iván Sánchez FernándezTobias Loddenkemper
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Nov 7, 2012·Pediatric Neurology·Iván Sánchez FernándezSanjeev V Kothare
May 7, 2013·Seizure : the Journal of the British Epilepsy Association·Sebastian FortiniRoberto Horacio Caraballo
Aug 30, 2011·Epilepsy & Behavior : E&B·Charline UrbainPatrick Van Bogaert
Apr 22, 2014·Epilepsy Research·Noémie LigotXavier De Tiège
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Jan 6, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Maxime NiesenXavier De Tiège
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Jan 21, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yuankai ZhuMei Tian
Sep 4, 2021·Frontiers in Aging Neuroscience·Delphine PuttaertXavier De Tiège

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