Metabolic fate of orally administered phyllodulcin in rats

Journal of Natural Products
Takaaki YasudaKeisuke Ohsawa

Abstract

Naturally occurring phyllodulcin (1) was orally administered to rats to investigate its metabolic fate. Urinary metabolites were analyzed by three-dimensional HPLC. Phyllodulcin-3'-O-sulfate (2), phyllodulcin-3'-O-beta-glucuronide (3), 2-[2-(3,4-dihydroxyphenyl)ethyl]-6-hydroxybenzoic acid (4), and one novel bibenzyl derivative, 2-[2-(3-hydroxy-4-methoxyphenyl)ethyl]-6-hydroxybenzoic acid (5), together with thunberginol G (6) and hydrangenol (7) were isolated from the phyllodulcin-treated urine. 1 was extensively metabolized to 4-6 by a rat fecal suspension after incubation for 24 h. Urinary excretion of 4-6 in rats administered phyllodulcin orally was substantially reduced when the rats were treated with antibiotics to suppress their intestinal flora. On the other hand, the incubation of 1 with rat liver S-9 mix showed the presence of 7 together with 4 and 5.

References

Jun 15, 1994·Biochemical Pharmacology·B L GoodwinM Sandler
May 30, 1998·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S E NielsenL O Dragsted
Mar 29, 2001·Bioscience, Biotechnology, and Biochemistry·A MurakamiK Koshimizu

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