Metabolic Fingerprint of Turner Syndrome

Journal of Clinical Medicine
Jolanta BugajskaKrystyna Sztefko

Abstract

Girls with Turner syndrome (TS) are at increased risk of developing insulin resistance and coronary artery disease as a result of hypertension and obesity frequently seen in these patients. On the other hand, it is known that obesity is associated with increased serum levels of branched-chain amino acids (BCAAs: valine; leucine and isoleucine) and aromatic amino acids. The aim of the study is to compare the metabolic fingerprint of girls with TS to the metabolic fingerprint of girls with obesity. Metabolic fingerprinting using an untargeted metabolomic approach was examined in plasma from 46 girls with TS (study group) and 22 age-matched girls with obesity (control group). The mean values of BCAAs, methionine, phenylalanine, lysine, tryptophan, histidine, tyrosine, alanine and ornithine were significantly lower in the study group than in the control (p from 0.0025 to <0.000001). Strong significant correlation between BCAAs, phenylalanine, arginine, tyrosine, glutamic acid, citrulline and alanine, and body mass index expressed as standard deviation score BMI-SDS in the patients with obesity (p from 0.049 to 0.0005) was found. In contrast; there was no correlation between these amino acids and BMI-SDS in the girls with TS. It is ...Continue Reading

References

Apr 1, 1991·The Journal of Clinical Endocrinology and Metabolism·S CaprioW V Tamborlane
Feb 25, 1998·Journal of Clinical Epidemiology·C H GravholtJ Hansen
Jan 7, 1999·Clinical Endocrinology·M Elsheikh, G S Conway
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Margareta BramnertLeif Groop
Aug 28, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mohammed El HafidiGuadalupe Baños
Dec 29, 2006·The Journal of Clinical Endocrinology and Metabolism·Liora SagiZe'ev Hochberg
Mar 20, 2008·The Journal of Clinical Endocrinology and Metabolism·Nicole WootenCarolyn A Bondy
Aug 2, 2008·Amino Acids·W W WangD F Li
Nov 8, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·R FernholmK Hall
Mar 23, 2011·Nature Medicine·Thomas J WangRobert E Gerszten
Apr 15, 2011·The Journal of Clinical Endocrinology and Metabolism·Christopher J ChildUNKNOWN GeNeSIS International Advisory Board
Mar 1, 2012·Clinical Endocrinology·Hong ZangPetra Tollet-Egnell
Dec 18, 2015·BBA Clinical·Meenal Mavinkurve, Clodagh S O'Gorman
Feb 20, 2016·Metabolism: Clinical and Experimental·Leonie H BoglKirsi H Pietiläinen
May 3, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S HaufeJ Jordan
Feb 10, 2018·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M Guevara-CruzL G Noriega
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Victoria L StevensSusan M Gapstur

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