Metabolic Flexibility Assists Reprograming of Central and Peripheral Innate Immunity During Neurodevelopment.

Molecular Neurobiology
Gabriela Cruz-Carrillo, Alberto Camacho-Morales

Abstract

Central innate immunity assists time-dependent neurodevelopment by recruiting and interacting with peripheral immune cells. Microglia are the major player of central innate immunity integrating peripheral signals arising from the circumventricular regions lacking the blood-brain barrier (BBB), via neural afferent pathways such as the vagal nerve and also by choroid plexus into the brain ventricles. Defective and/or unrestrained activation of central and peripheral immunity during embryonic development might set an aberrant connectome establishment and brain function, leading to major psychiatric disorders in postnatal stages. Molecular candidates leading to central and peripheral innate immune overactivation identified metabolic substrates and lipid species as major contributors of immunological priming, supporting the role of a metabolic flexibility node during trained immunity. Mechanistically, trained immunity is established by an epigenetic program including DNA methylation and histone acetylation, as the major molecular epigenetic signatures to set immune phenotypes. By definition, immunological training sets reprogramming of innate immune cells, enhancing or repressing immune responses towards a second challenge which pot...Continue Reading

References

Nov 1, 1992·Scandinavian Journal of Immunology·J W van 't WoutR van Furth
Feb 7, 1997·Schizophrenia Research·P O'ConnellR M Murray
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Meiling LuRichard J Miller
Jun 5, 2003·Nature Reviews. Neuroscience·Phuong B Tran, Richard J Miller
Sep 27, 2003·Journal of Neurochemistry·Tiina SuuronenAntero Salminen
Jan 28, 2004·British Journal of Pharmacology·Jari HuuskonenAntero Salminen
Jul 26, 2005·Trends in Immunology·Britta Engelhardt, Richard M Ransohoff
May 13, 2006·Endocrinology·Matthew D Anway, Michael K Skinner
Jun 3, 2008·Journal of Molecular Endocrinology·Kjersti M Aagaard-TilleryRobert H Lane
Aug 30, 2008·Biochimica Et Biophysica Acta·Ronen Marmorstein, Raymond C Trievel
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bastiaan T HeijmansL H Lumey
Dec 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Justin D LathiaMark P Mattson
Jan 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marciane MilanskiLício A Velloso
Feb 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Charlotte D'MelloMark G Swain
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chul-Su YangEun-Kyeong Jo
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael T McCabePaula M Vertino
Aug 7, 2009·Human Molecular Genetics·Elmar W TobiBastiaan T Heijmans
Sep 10, 2009·Frontiers in Behavioral Neuroscience·Staci D Bilbo, Jaclyn M Schwarz
Oct 2, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gregory Z Tau, Bradley S Peterson
Feb 17, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Hyeon-Sook SuhSunhee C Lee
Jul 21, 2010·Infection and Immunity·Natalia MuñozJosé A Chabalgoity
Oct 12, 2010·PloS One·Carlos Guerrero-BosagnaMichael K Skinner
Nov 12, 2010·Nature·Edwige NicodemeAlexander Tarakhovsky
Dec 17, 2010·Nature·Alvaro Rada-IglesiasJoanna Wysocka
Feb 2, 2011·Experimental Neurology·Stephen G Matthews, David I Phillips
Feb 16, 2011·Cell Research·Andrew J Bannister, Tony Kouzarides
May 18, 2011·Cell Host & Microbe·Mihai G NeteaJos W M van der Meer

❮ Previous
Next ❯

Methods Mentioned

BETA
histone acetylation
biopsy
acetylation

Software Mentioned

BioRender

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.