Metabolic fuel kinetics in fish: swimming, hypoxia and muscle membranes

The Journal of Experimental Biology
Jean-Michel WeberTeye Omlin

Abstract

Muscle performance depends on the supply of metabolic fuels and disposal of end-products. Using circulating metabolite concentrations to infer changes in fluxes is highly unreliable because the relationship between these parameters varies greatly with physiological state. Quantifying fuel kinetics directly is therefore crucial to the understanding of muscle metabolism. This review focuses on how carbohydrates, lipids and amino acids are provided to fish muscles during hypoxia and swimming. Both stresses force white muscle to produce lactate at higher rates than it can be processed by aerobic tissues. However, lactate accumulation is minimized because disposal is also strongly stimulated. Exogenous supply shows that trout have a much higher capacity to metabolize lactate than observed during hypoxia or intense swimming. The low density of monocarboxylate transporters and their lack of upregulation with exercise explain the phenomenon of white muscle lactate retention. This tissue operates as a quasi-closed system, where glycogen stores act as an 'energy spring' that alternates between explosive power release during swimming and slow recoil from lactate in situ during recovery. To cope with exogenous glucose, trout can completely...Continue Reading

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Citations

Jan 31, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Johnathon L I ForbesJean-Michel Weber
Jan 31, 2020·Biology Open·Jacqueline WeidnerChristian Jørgensen
Feb 27, 2020·The Journal of Experimental Biology·Krista Kraskura, Jay A Nelson
Jul 17, 2018·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Connie E Short, William R Driedzic
Apr 21, 2020·BMC Genomics·Cláudia Raposo de MagalhãesMarco Cerqueira
Dec 8, 2017·The Journal of Experimental Biology·Eric D Turenne, Jean-Michel Weber
Nov 27, 2019·The Journal of Experimental Biology·Johnathon L I ForbesJean-Michel Weber
Jul 1, 2017·Integrative and Comparative Biology·Kang Nian YapTony D Williams
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Jan 3, 2019·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Li LiKenneth B Storey
Dec 23, 2020·Journal of Fish Biology·Andrea J MorashSuzanne Currie
Aug 11, 2021·The Journal of Experimental Biology·Mais JubouriJan A Mennigen

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