PMID: 11912449Mar 26, 2002Paper

Metabolic gaps in bone formation may be a novel marker to monitor the osseous metastasis of prostate cancer

The Journal of Urology
Mitsuru KoizumiEtsuro Ogata

Abstract

Although skeletal metastasis is a common complication associated with prostate cancer, assessment of the response of osseous metastasis to therapy is still difficult. To remedy this situation a study of bone formation metabolic markers gaps in patients with prostate cancer and osseous metastasis was done to determine these gaps as clinical markers for the efficacy of therapy against osseous metastasis. The activities of the bone formation markers amino terminal propeptide of type I procollagen (PINP), bone alkaline phosphatase (BAP) and osteocalcin (OC) were measured in 57 and 60 patients with prostate cancer without and with osseous metastasis, respectively. Of the 60 patients with osseous metastasis serial measurements were performed in 31. The status of osseous metastasis at the time of marker measurement was categorized, and the BAP-to-PINP, OC-to-PINP and OC-to-BAP ratios were calculated. The BAP-to-PINP ratio did not change. However, the OC-to-PINP and OC-to-BAP ratios were significantly different depending on osseous metastasis status. The ratios were high in patients with no osseous metastasis or with metastasis shrinkage (improvement) but low in those in whom metastases were growing and/or spreading (progression). Cuto...Continue Reading

Citations

Jul 20, 2002·Annals of Nuclear Medicine·Mitsuru Koizumi, Etsuro Ogata
Oct 6, 2005·Nature Clinical Practice. Oncology·Markus J Seibel
Dec 17, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·T Lebret, A Méjean
Oct 24, 2007·The Veterinary Clinics of North America. Small Animal Practice·Timothy M Fan
Jul 15, 2004·International Journal of Cancer. Journal International Du Cancer·Klaus JungDietmar Schnorr

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