Metabolic glycan labeling-assisted discovery of cell-surface markers for primary neural stem and progenitor cells

Chemical Communications : Chem Comm
Qing-Ran BaiQin Shen

Abstract

A chemical approach was developed for identifying cell-surface markers for primary neural stem cells (NSCs). Using an in vitro coculture system of primary NSCs combined with metabolic labeling of sialoglycans with bioorthogonal functional groups, we selectively enriched and identified a list of cell-surface sialoglycoproteins that were more abundantly expressed in neural stem and progenitor cells.

References

Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·N UchidaI L Weissman
Nov 2, 2001·Nature·S Temple
Jan 27, 2011·PLoS Biology·Graciana Diez-RouxAndrea Ballabio
May 10, 2011·Cell Stem Cell·Erika PastranaFiona Doetsch
Sep 12, 2013·Stem Cells·Brian DeVealeDerek van der Kooy
Nov 5, 2013·Neuron·Fred H Gage, Sally Temple
Nov 18, 2015·Chembiochem : a European Journal of Chemical Biology·Bo ChengXing Chen

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Citations

Jul 28, 2021·Annual Review of Analytical Chemistry·Bo ChengXing Chen

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Methods Mentioned

BETA
glycosylation
FACS

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