Metabolic glycan labelling for cancer-targeted therapy.

Nature Chemistry
Hua Wang, David J Mooney

Abstract

Metabolic glycoengineering with unnatural sugars provides a powerful tool to label cell membranes with chemical tags for subsequent targeted conjugation of molecular cargos via efficient chemistries. This technology has been widely explored for cancer labelling and targeting. However, as this metabolic labelling process can occur in both cancerous and normal cells, cancer-selective labelling needs to be achieved to develop cancer-targeted therapies. Unnatural sugars can be either rationally designed to enable preferential labelling of cancer cells, or specifically delivered to cancerous tissues. In this Review Article, we will discuss the progress to date in design and delivery of unnatural sugars for metabolic labelling of tumour cells and subsequent development of tumour-targeted therapy. Metabolic cell labelling for cancer immunotherapy will also be discussed. Finally, we will provide a perspective on future directions of metabolic labelling of cancer and immune cells for the development of potent, clinically translatable cancer therapies.

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·H HaiglerS Cohen
Apr 1, 1981·Journal of Neurochemistry·W FerwerdaJ Heijlman
Jan 20, 1999·Biochimie·M TonettiA De Flora
Mar 4, 2000·Advanced Drug Delivery Reviews·J Sudimack, R J Lee
Sep 8, 2000·The Journal of Biological Chemistry·T LiuH J Jennings
Jun 30, 2001·The New England Journal of Medicine·C L Shapiro, A Recht
Oct 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R I NicholsonM E Harper
Dec 12, 2002·Journal of the American Chemical Society·Eliana SaxonCarolyn R Bertozzi
Sep 13, 2003·Methods in Enzymology·Sarah J LuchanskyCarolyn R Bertozzi
Oct 29, 2003·Current Opinion in Chemical Biology·Danielle H Dube, Carolyn R Bertozzi
Mar 5, 2004·Chembiochem : a European Journal of Chemical Biology·Sarah J LuchanskyCarolyn R Bertozzi
Mar 30, 2004·The Journal of Biological Chemistry·Wei ZouHarold J Jennings
May 12, 2004·Nature Reviews. Drug Discovery·Napoleone FerraraWilliam Novotny
Mar 15, 2006·Biochemistry·Peter ChefaloClifford V Harding
Nov 23, 2006·Methods in Enzymology·Scott T LaughlinCarolyn R Bertozzi
Feb 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tsui-Ling HsuChi-Huey Wong
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kwangjae ChoDong M Shin
May 3, 2008·Science·Scott T LaughlinCarolyn R Bertozzi
Jul 4, 2008·Nature Reviews. Cancer·Lee M Ellis, Daniel J Hicklin
Sep 30, 2008·Bioorganic & Medicinal Chemistry Letters·Laila DafikKrishna Kumar
Oct 9, 2008·Advanced Drug Delivery Reviews·James D ByrneLisa Brannon-Peppas
Mar 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Wen YiPeng George Wang
Apr 24, 2009·Angewandte Chemie·Pamela V ChangPeng Wu
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Pamela V ChangCarolyn R Bertozzi
May 5, 2010·Journal of Medicinal Chemistry·Laila DafikKrishna Kumar
Jun 24, 2010·Journal of the American Chemical Society·Pamela V ChangCarolyn R Bertozzi
Aug 28, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fabienne DanhierVéronique Préat
Sep 15, 2010·Nature Reviews. Clinical Oncology·Rakesh K Jain, Triantafyllos Stylianopoulos
Aug 16, 2011·Bioconjugate Chemistry·Michelle R BondJennifer J Kohler
Aug 17, 2011·Journal of Pharmacological and Toxicological Methods·U Iyer, V J Kadambi
Sep 29, 2011·Bioconjugate Chemistry·Mark R KarverScott A Hilderbrand
Mar 13, 2012·International Journal of Medical Sciences·Rajamanickam BaskarKheng-Wei Yeoh
Jun 1, 2012·Journal of the American Chemical Society·Ran XieXing Chen

❮ Previous
Next ❯

Citations

Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Asuka ShirakawaKoichi Fukase
May 14, 2021·Organic & Biomolecular Chemistry·Daniela ImperioLuigi Panza
May 14, 2021·APL Bioengineering·Sheng MaWantong Song
May 29, 2021·Mass Spectrometry Reviews·Fangxu SunRonghu Wu
Jul 20, 2021·Chemical Science·Chad PlumetSébastien Papot
Aug 19, 2021·Chembiochem : a European Journal of Chemical Biology·Shreyas P Vaidya, Malay Patra
Oct 7, 2021·Electrophoresis·Cristian D Gutierrez-ReyesYehia Mechref
Nov 17, 2021·Biochemical Society Transactions·Yun Ge, Christina M Woo

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation
surgical resection

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.