Metabolic Hallmarks of Metastasis Formation.

Trends in Cell Biology
Ilaria EliaSarah-Maria Fendt

Abstract

Metastasis to distant organs is a predictor of poor prognosis. Therefore, it is of paramount importance to understand the mechanisms that impinge on the different steps of the metastatic cascade. Recent work has revealed that particular metabolic pathways are rewired in cancer cells to support their transition through the metastatic cascade, resulting in the formation of secondary tumors in distant organs. Indeed, metabolic rewiring induces signaling pathways during initial cancer invasion, circulating cancer cells depend on enhanced antioxidant defenses, and cancer cells colonizing a distant organ require increased ATP production. Moreover, the local environment of the metastatic niche dictates the metabolic pathways secondary tumors rely on. Here we describe mechanisms of metabolic rewiring associated with distinct steps of metastasis formation.

Citations

Jul 13, 2019·BMC Biology·Sarah-Maria Fendt
Oct 17, 2019·Cold Spring Harbor Perspectives in Medicine·Nina C FlerinMassimiliano Mazzone
Sep 24, 2020·EMBO Reports·Patricia Altea-ManzanoSarah-Maria Fendt
Mar 28, 2019·Nature Reviews. Clinical Oncology·Xiaoyun LiPing-Chih Ho
Apr 24, 2019·International Journal of Molecular Sciences·Bárbara SousaJoana Paredes
May 10, 2019·Frontiers in Oncology·Ginevra DoglioniSarah-Maria Fendt
Jul 29, 2018·Journal of Experimental & Clinical Cancer Research : CR·Go J Yoshida
Dec 4, 2019·Scientific Reports·Bing-Syuan NiJen-Huang Huang
Jan 11, 2020·Frontiers in Oncology·Wei MuMargot Zöller
Dec 22, 2019·Genes·Marina Ayres Pereira, Iok In Christine Chio
Aug 21, 2020·Nature·Barbara M Grüner, Sarah-Maria Fendt
Aug 15, 2018·Disease Models & Mechanisms·Alexander MuirMatthew G Vander Heiden
Oct 29, 2020·The Journal of Biological Chemistry·Emily M ChristensenJohn J Tanner
Nov 4, 2020·Cancer Discovery·Sarah-Maria FendtAyelet Erez
Jan 20, 2021·Nature Reviews. Cancer·Gabriele Bergers, Sarah-Maria Fendt
Sep 14, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Bárbara SousaJoana Paredes
Feb 13, 2020·Cancer Cell·Sarah-Maria Fendt, Sophia Y Lunt
Jan 19, 2020·Trends in Cancer·Shawn McGuirkJulie St-Pierre
Jan 9, 2021·Cancer & Metabolism·Shilpa R NagarajanAndrew J Hoy
Oct 30, 2020·Frontiers in Oncology·Rodolfo Chavez-DominguezDolores Aguilar-Cazares
Oct 22, 2020·Cells·Jae Hyung ParkHyun Woo Park
Jan 1, 2021·Cancer Management and Research·Yutong XingJie Jiang
Dec 10, 2020·Cancer & Metabolism·H Furkan AlkanJuliane G Bogner-Strauss
Nov 24, 2020·Frontiers in Oncology·Kara WolfeAtsuo T Sasaki
Sep 3, 2019·The Journal of Investigative Dermatology·Guannan ZhuChunying Li
May 8, 2019·Developmental Cell·Yang GaoXiang H-F Zhang
Jan 18, 2021·The Journal of Biological Chemistry·Emily M ChristensenJohn J Tanner
Mar 20, 2021·Trends in Cancer·Erica PranziniMaria Letizia Taddei
Apr 4, 2021·Cells·Hengbo ZhouTimothy P Padera
Apr 4, 2021·Cell Metabolism·Liwen ZhangPengcheng Bu
Apr 12, 2021·Neoplasia : an International Journal for Oncology Research·Jeremy JohnsonPiotr Rychahou
May 1, 2021·Experimental Hematology & Oncology·Chao Wang, Daya Luo
May 1, 2021·Cancers·Josep Tarragó-Celada, Marta Cascante
May 2, 2021·Cancer & Metabolism·Violet A KieselDorothy Teegarden
Jul 2, 2019·Cell·Clotilde WielMartin O Bergo

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