Metabolic Health, Insulin, and Breast Cancer: Why Oncologists Should Care About Insulin.

Frontiers in Endocrinology
Lisa D YeeVictoria L Seewaldt

Abstract

Studies investigating the potential link between adult pre-menopausal obesity [as measured by body mass index (BMI)] and triple-negative breast cancer have been inconsistent. Recent studies show that BMI is not an exact measure of metabolic health; individuals can be obese (BMI > 30 kg/m2) and metabolically healthy or lean (BMI < 25 kg/m2) and metabolically unhealthy. Consequently, there is a need to better understand the molecular signaling pathways that might be activated in individuals that are metabolically unhealthy and how these signaling pathways may drive biologically aggressive breast cancer. One key driver of both type-2 diabetes and cancer is insulin. Insulin is a potent hormone that activates many pathways that drive aggressive breast cancer biology. Here, we review (1) the controversial relationship between obesity and breast cancer, (2) the impact of insulin on organs, subcellular components, and cancer processes, (3) the potential link between insulin-signaling and cancer, and (4) consider time points during breast cancer prevention and treatment where insulin-signaling could be better controlled, with the ultimate goal of improving overall health, optimizing breast cancer prevention, and improving breast cancer ...Continue Reading

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Citations

Oct 2, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·David E FrankhauserVictoria L Seewaldt
Jan 23, 2021·Biomolecules·Federica BielloAlessandra Gennari
Nov 17, 2020·Frontiers in Public Health·Veronica C JonesVictoria L Seewaldt
Jul 27, 2021·Current Opinion in Pharmacology·Antonio J León-GonzálezRaúl M Luque

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Methods Mentioned

BETA
biopsy
GTPases

Clinical Trials Mentioned

NCT01101438
NCT01793948
NCT01905046
NCT02028221

Software Mentioned

DPPOS

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