Metabolic Impacts of Maltase Deficiencies

Journal of Pediatric Gastroenterology and Nutrition
Buford L NicholsRoberto Quezada-Calvillo

Abstract

The mucosal maltase enzymes are characterized by an activity that produces glucose from linear glucose polymers, assayed with the disaccharide maltose. The related enzyme isomaltase produces glucose from branched glucose polymers, assayed with palatinose. Maltase and isomaltase activities are part of the 4 disaccharidases assayed from clinical duodenal biopsy homogenates. The reported maltase activities are more difficult to interpret than lactase or sucrase activities because both the sucrase-isomaltase and maltase-glucoamylase proteins have overlapping maltase activities. The early work of Dahlqvist identified 4 maltase activities from human small intestinal mucosa. On one peptide, sucrase (maltase Ib) and isomaltase (maltase Ia) activities shared maltase activities but identified the enzymes as sucrase-isomaltase. On the other peptide, no distinguishing characteristics of the 2 maltase activities (maltases II and III) were detected and the activities identified as maltase-glucoamylase. The nutritional/clinical importance of small intestinal maltase and isomaltase activities are due to their crucial role in the digestion of food starches to absorbable free glucose. This review focuses on the interpretation of biopsy maltase a...Continue Reading

References

Apr 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·A Dahlqvist
Jan 1, 1993·Archives of Disease in Childhood·P McClean, L T Weaver
Feb 28, 1998·The Journal of Biological Chemistry·B L NicholsE Sterchi
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Buford L NicholsErwin E Sterchi
Jan 10, 2006·American Journal of Human Genetics·Mikko KuokkanenIrma Jarvela
Mar 10, 2007·Nutrition Reviews·Claudia C Robayo-Torres, Buford L Nichols
Jun 23, 2007·The Journal of Nutrition·Roberto Quezada-CalvilloBuford L Nichols
Jun 27, 2007·Journal of Pediatric Gastroenterology and Nutrition·Roberto Quezada-CalvilloBuford L Nichols
Nov 1, 2012·Journal of Pediatric Gastroenterology and Nutrition·Buford L Nichols, Salvatore Auricchio
Nov 1, 2012·Journal of Pediatric Gastroenterology and Nutrition·Buford L NicholsSusan S Baker
Nov 1, 2012·Journal of Pediatric Gastroenterology and Nutrition·Claudia C Robayo-TorresAntone R Opekun
Nov 1, 2012·Journal of Pediatric Gastroenterology and Nutrition·William R Treem
Jul 11, 2013·Journal of Pediatric Gastroenterology and Nutrition·Maricela Diaz-SotomayorBuford L Nichols
Mar 8, 2017·Journal of Pediatric Gastroenterology and Nutrition·Buford L NicholsSen-Ichi Oda

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Citations

Feb 7, 2020·Animal : an International Journal of Animal Bioscience·D L Harmon, K C Swanson
Feb 12, 2020·Molecular Nutrition & Food Research·Xin Qi, Richard F Tester
May 16, 2018·Journal of Pediatric Gastroenterology and Nutrition·Bruno P ChumpitaziMark A Gilger
May 16, 2018·Journal of Pediatric Gastroenterology and Nutrition·Stanley A CohenHeather E Elser
Dec 21, 2019·The Clinical Biochemist. Reviews·Matthew Burke
Aug 1, 2020·Journal of Pediatric Gastroenterology and Nutrition·Chirajyoti DebDevendra I Mehta
May 16, 2018·Journal of Pediatric Gastroenterology and Nutrition·Buford Nichols, William J Klish
Jun 19, 2021·World Journal of Clinical Cases·Saria DbarAlina Makarova

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