Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans.

Journal of Lipid Research
Kim H H LissAngela M Hall

Abstract

Adipocyte triglyceride storage provides a reservoir of energy that allows the organism to survive times of nutrient scarcity, but excessive adiposity has emerged as a health problem in many areas of the world. Monoacylglycerol acyltransferase (MGAT) acylates monoacylglycerol to produce diacylglycerol; the penultimate step in triglyceride synthesis. However, little is known about MGAT activity in adipocytes, which are believed to rely primarily on another pathway for triglyceride synthesis. We show that expression of the gene that encodes MGAT1 is robustly induced during adipocyte differentiation and that its expression is suppressed in fat of genetically-obese mice and metabolically-abnormal obese human subjects. Interestingly, MGAT1 expression is also reduced in physiologic contexts where lipolysis is high. Moreover, knockdown or knockout of MGAT1 in adipocytes leads to higher rates of basal adipocyte lipolysis. Collectively, these data suggest that MGAT1 activity may play a role in regulating basal adipocyte FFA retention.

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Citations

Apr 27, 2020·Archives of Insect Biochemistry and Physiology·Umut ToprakGözde Güney
Sep 17, 2019·The Journal of Clinical Investigation·Gordon I SmithSamuel Klein
Sep 12, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kim H H LissBrian N Finck

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Methods Mentioned

BETA
acylation
Knockout
transgenic
PCR

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