Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease.

World Journal of Gastroenterology : WJG
Angeliki KatsarouAntonios Chatzigeorgiou

Abstract

Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive storage of fatty acids in the form of triglycerides in hepatocytes. It is most prevalent in western countries and includes a wide range of clinical and histopathological findings, namely from simple steatosis to steatohepatitis and fibrosis, which may lead to cirrhosis and hepatocellular cancer. The key event for the transition from steatosis to fibrosis is the activation of quiescent hepatic stellate cells (qHSC) and their differentiation to myofibroblasts. Pattern recognition receptors (PRRs), expressed by a plethora of immune cells, serve as essential components of the innate immune system whose function is to stimulate phagocytosis and mediate inflammation upon binding to them of various molecules released from damaged, apoptotic and necrotic cells. The activation of PRRs on hepatocytes, Kupffer cells, the resident macrophages of the liver, and other immune cells results in the production of proinflammatory cytokines and chemokines, as well as profibrotic factors in the liver microenvironment leading to qHSC activation and subsequent fibrogenesis. Thus, elucidation of the inflammatory pathways associated with the pathogenesis and progression of NAFLD ma...Continue Reading

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Citations

Dec 4, 2020·Expert Review of Gastroenterology & Hepatology·Yusuf YilmazGiovanni Musso
Dec 19, 2020·Ultrasonics·Tu-Yung ChangPo-Hsiang Tsui
Dec 8, 2020·Molecular Metabolism·Sharon O Jensen-Cody, Matthew J Potthoff
Feb 8, 2021·Annals of Hepatology·Alan Eduardo Botello-ManillaNatalia Nuño-Lámbarri
Apr 4, 2021·International Journal of Molecular Sciences·Ioannis I MoustakasAntonios Chatzigeorgiou
Jun 3, 2021·International Journal of Molecular Sciences·Raquel CanoValmore Bermúdez
Jul 3, 2021·International Journal of Molecular Sciences·Siarhei A DabravolskiAlexander N Orekhov
Aug 28, 2021·International Journal of Molecular Sciences·Lampros ChrysavgisAntonios Chatzigeorgiou
Jul 24, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan WanYi Ding
Oct 7, 2021·Diabetes & Metabolism Journal·Inês Sousa-LimaYoung-Bum Kim

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Methods Mentioned

BETA
biopsy
biopsies
Gastric Bypass

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