Metabolic interfaces between growth and reproduction. I. Nutritional modulation of gonadotropin, prolactin, and growth hormone secretion in the growth-limited female lamb

Endocrinology
D L FosterD E Fenner

Abstract

The acute and long term effects of dietary restrictions on gonadotropin secretion were studied in ovariectomized female lambs. Nutritionally growth-restricted lambs which were chronically maintained at a body weight comparable to that at weaning (approximately 20 kg) became hypogonadotropic, exhibiting a low frequency of episodic LH discharges. Repeated administration of physiological doses of GnRH to these females at hourly intervals produced corresponding LH pulses, leading to the hypothesis that the dietary-induced hypogonadotropism arises from a deficiency in endogenous GnRH release, rather than an inability of the pituitary gland to secrete gonadotropins in response to hypothalamic stimulation. In such growth-restricted females receiving a single meal daily, initiation of ad libitum feeding led to a spontaneous LH pulse within 1 h. After 14 days of increased food intake, hourly LH pulses were evident; a marked reduction in LH pulse frequency was associated with the return to limited nutrition. No effects on pulse amplitude were evident. Changes in circulating FSH followed a pattern similar to that for LH, namely an increase in concentration with improved nutrition and a decrease with reduced nutrition. The rate of response...Continue Reading

Citations

Jul 1, 1993·Fish Physiology and Biochemistry·F Le GacC Weil
Oct 1, 1990·Domestic Animal Endocrinology·F C Buonomo, C A Baile
Jul 1, 1995·Trends in Endocrinology and Metabolism : TEM·M Bergendahl, J D Veldhuis
Jan 23, 1998·Domestic Animal Endocrinology·E GootwineG W Montgomery
Jan 1, 1990·Nutrition Research Reviews·R J Ross, C R Buchanan
Jan 1, 1995·Nutrition Research Reviews·H Kaur, S P Arora
May 21, 2011·Human Molecular Genetics·Wanda S LaymanDonna M Martin
Sep 28, 2007·Neuroendocrinology·Angelena CrownRobert A Steiner
May 1, 2004·The Journal of Reproduction and Development·Katsuyasu SakuraiHiroaki Okamura
Apr 24, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jose DonatoCarol F Elias
Mar 1, 1994·The Proceedings of the Nutrition Society·C L Adam, J J Robinson
Oct 22, 2008·Animal Reproduction Science·M A De Santiago-MiramontesJ A Delgadillo
Mar 11, 2008·Ageing Research Reviews·Bronwen MartinStuart Maudsley
Mar 1, 1992·Hormones and Behavior·J E Schneider
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·G N Wade, J E Schneider
Jun 2, 2005·Domestic Animal Endocrinology·D A ZiebaG L Williams
May 11, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Sebastián EscobarManuel Carrillo
Jan 23, 1999·Biology of Reproduction·M J CunninghamR A Steiner
Nov 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·George N Wade, Juli E Jones
Dec 24, 2018·Reproduction in Domestic Animals = Zuchthygiene·María P TurielloCecilia I Merkis
May 15, 2003·Endocrinology·Kazuhiro KawamuraToshinobu Tanaka

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