Metabolic Kinases Moonlighting as Protein Kinases

Trends in Biochemical Sciences
Zhimin Lu, Tony Hunter

Abstract

Protein kinases regulate every aspect of cellular activity, whereas metabolic enzymes are responsible for energy production and catabolic and anabolic processes. Emerging evidence demonstrates that some metabolic enzymes, such as pyruvate kinase M2 (PKM2), phosphoglycerate kinase 1 (PGK1), ketohexokinase (KHK) isoform A (KHK-A), hexokinase (HK), and nucleoside diphosphate kinase 1 and 2 (NME1/2), that phosphorylate soluble metabolites can also function as protein kinases and phosphorylate a variety of protein substrates to regulate the Warburg effect, gene expression, cell cycle progression and proliferation, apoptosis, autophagy, exosome secretion, T cell activation, iron transport, ion channel opening, and many other fundamental cellular functions. The elevated protein kinase functions of these moonlighting metabolic enzymes in tumor development make them promising therapeutic targets for cancer.

Citations

Jun 28, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nils G Walter
Sep 10, 2019·Proteome Science·Qiwen LiJun Liu
Nov 1, 2018·Cancer Communications·Yugang WangZhimin Lu
Oct 28, 2018·Cancer Communications·Sean Lu, Yugang Wang
Oct 24, 2019·FEBS Letters·Vivian M LiuMatthew G Vander Heiden
Sep 2, 2020·Cellular and Molecular Life Sciences : CMLS·Amina Jamal LahamRaafat El-Awady
Oct 23, 2019·Scientific Reports·Jesús Gómez-EscuderoAlicia G Arroyo
Sep 20, 2020·International Journal of Molecular Sciences·Florian GeorgescauldAlain Dautant
Jun 23, 2018·Nature Reviews. Molecular Cell Biology·Xinjian LiZhimin Lu
Jul 6, 2020·Antioxidants & Redox Signaling·Jennifer Selinski, Renate Scheibe
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