Metabolic manifestations of polycystic ovary syndrome in nonobese adolescents: retinol-binding protein 4 and ectopic fat deposition.

Fertility and Sterility
Aviva B SopherSharon E Oberfield

Abstract

To determine whether nonobese adolescents with polycystic ovary syndrome (PCOS) have higher levels of retinol-binding protein 4 (RBP4) and ectopic fat than controls and whether RBP4 and ectopic fat correlate with comorbidities of metabolic disease. Cross-sectional case-control study. Pediatric clinical research center based in a quaternary care medical center. Twenty-four nonobese adolescents between the ages of 13 and 21 years, 13 with PCOS and 11 controls. Measurement of RBP4, insulin resistance, lipids, and body composition. Retinol-binding protein 4, reproductive and adrenal hormones, insulin resistance, intrahepatic and intramyocellular lipid levels, and visceral adipose tissue. Adolescents with PCOS had higher intrahepatic lipid content and a statistical trend for higher RBP4 compared with controls. Retinol-binding protein 4 correlated with body fat, triglycerides, insulin resistance, and androgens but not intrahepatic lipid content; however, when adjusted for body fat, the correlation between RBP4 and triglycerides weakened to a statistical trend and was no longer statistically significant for the other measures. This small preliminary study of nonobese adolescent girls suggests that RBP4 may be involved in the dyslipide...Continue Reading

References

Feb 1, 1990·Diabetes Care·J P Le FlochL Perlemuter
Jun 22, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A AvignonL Monnier
Nov 1, 1961·The Journal of Clinical Endocrinology and Metabolism·D FERRIMAN, J D GALLWEY
Jan 7, 2006·Nature Medicine·Yoshikazu TamoriMasato Kasuga
Feb 24, 2006·The Journal of Clinical Endocrinology and Metabolism·Tracy L SetjiAnn J Brown
Jun 16, 2006·The New England Journal of Medicine·Timothy E GrahamBarbara B Kahn
Dec 15, 2006·Nature·Jean-Pierre Després, Isabelle Lemieux
Feb 9, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Maya Gambarin-GelwanWalter Futterweit
Feb 13, 2007·Metabolism: Clinical and Experimental·Duk-Chul LeeJee-Aee Im
Mar 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Prabhakaran BalagopalDonald George
Jun 15, 2007·Journal of Hepatology·Cristián CerdaMarco Arrese
Jul 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kitt Falk PetersenGerald I Shulman
Aug 28, 2007·Lancet·Robert J NormanTheresa E Hickey
Aug 30, 2007·The Journal of Clinical Endocrinology and Metabolism·Isabelle AeberliMichael B Zimmermann
Apr 9, 2008·Diabetes Care·Samantha K HutchisonHelena J Teede
May 20, 2008·Clinical Chemistry·Christina Kanaka-GantenbeinIoannis Papassotiriou
Oct 28, 2008·Fertility and Sterility·Ricardo AzzizUNKNOWN Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society
Nov 7, 2008·Clinical Pediatrics·Sue Abell, John L Ey
Nov 26, 2008·Fertility and Sterility·Te-Fu ChanEing-Mei Tsai
Jan 23, 2009·The Journal of Clinical Endocrinology and Metabolism·Elmar AignerChristian Datz
May 21, 2009·The Journal of Clinical Endocrinology and Metabolism·Jean-Baptiste ArmengaudMartin Chalumeau
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elisa FabbriniSamuel Klein
Feb 18, 2010·Reproductive Biomedicine Online·Bulent O YildizHakan Yarali
Apr 15, 2010·Hormone Research in Pædiatrics·D YesteA Carrascosa
May 4, 2010·American Journal of Obstetrics and Gynecology·Enrico CarminaRogerio A Lobo
Aug 13, 2011·European Journal of Endocrinology·Primoz KotnikMartin Wabitsch
Dec 8, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Aviva B SopherSharon E Oberfield

❮ Previous
Next ❯

Citations

Jan 22, 2013·Journal of Molecular Endocrinology·Xinwang ChenJihong Kang
Oct 19, 2012·Current Opinion in Endocrinology, Diabetes, and Obesity·Katrina F Nicandri, Kathleen Hoeger
Feb 22, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Saba NikanfarRalf Dittrich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.