Metabolic mapping of functional activity in human subjects with the [18F]fluorodeoxyglucose technique

Science
J GreenbergA Wolf

Abstract

The 2-[18F]fluoro-2-deoxy-D-glucose technique was used to measure regional cerebral glucose utilization by human subjects during functional activation. Normal male volunteers subjected to one or more sensory stimuli (tactile, visual, or auditory) exhibited focal increases in glucose metabolism in response to the stimulus. Unilateral visual hemifield stimulation caused the contralateral striate cortex to become more metabolically active than the striate cortex ipsilateral to the stimulated hemifield. Similarly, stroking the fingers and hand of one arm with brush produced an increase in metabolism in the contralateral postcentral gyrus, compared with the homologous ipsilateral region. The auditory stimulus, which consisted of a monaurally presented factual story caused an increase in glucose metabolism in the auditory cortex in the hemisphere contralateral to the stimulated ear. These results demonstrate that the technique is capable of providing functional maps in vivo related to both body region and submodality of sensory information in the human brain.

References

Nov 1, 1978·Journal of Computer Assisted Tomography·M M Ter-PogossianD C Ficke
Jun 1, 1979·Journal of Computer Assisted Tomography·E J HoffmanM E Phelps
Oct 1, 1977·Seminars in Nuclear Medicine·M E Phelps
Jan 1, 1975·Radiology·M M Ter-PogossianN A Mullani
May 1, 1968·The Journal of Physiology·G S Brindley, W S Lewin
Nov 1, 1971·Journal of Neurophysiology·B L WhitselJ R Roppolo
May 1, 1952·Journal of Neurology, Neurosurgery, and Psychiatry·J M SPALDING
Jul 1, 1918·The British Journal of Ophthalmology·G Holmes

❮ Previous
Next ❯

Citations

Jun 1, 1994·Annals of Neurology·J R BinderV M Haughton
Aug 30, 2008·Cochlear Implants International·K M J GreenD E L Hastings
Oct 11, 2008·Cochlear Implants International·Kevin M J GreenDavid L Hastings
Sep 1, 1991·Neurochemical Research·M E Phelps
Dec 1, 1982·Journal of Medical Systems·M M Ter-Pogossian
Dec 25, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Stelvio SestiniLuigi Mansi
Nov 1, 1983·The International Journal of Applied Radiation and Isotopes·S LevyG L Brownell
May 24, 1982·Life Sciences·T C RainbowW V Bleisch
Jan 1, 1984·Clinical Neurology and Neurosurgery·A A Lammertsma
Jan 1, 1989·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·R W ParksP L McGeer
Jan 1, 1990·Research in Developmental Disabilities·J L Mosley, M I Vrbancic
May 1, 1991·Epilepsy Research·E B BromfieldW H Theodore
May 23, 2007·The Journal of Laryngology and Otology·K M J GreenR T Ramsden
Jan 31, 2013·Seminars in Neurology·Brian L Edlow, Ona Wu
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·R G ShulmanF Hyder
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·M E Phelps
Mar 15, 1986·American Journal of Ophthalmology·M KiyosawaT Ido
Apr 15, 1988·American Journal of Ophthalmology·J L DemerK L Gould
Jan 1, 1986·Neuropsychologia·W D HeissK Wienhard
Jan 1, 1983·Neuropsychologia·R C GurM Reivich
Sep 7, 2001·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·A B Newberg, A Alavi
Jul 3, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Abass Alavi, Sandip Basu
Jan 1, 1982·Advances in Enzyme Regulation·E J CrawfordA Goldin
Jul 23, 2005·The Journal of Physiology·Jukka KemppainenJuhani Knuuti
Oct 8, 2013·Seminars in Nuclear Medicine·Ilya Nasrallah, Jacob Dubroff
Sep 1, 1983·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·G M PelamattiG Castagneri
Feb 18, 2016·International Journal of Biomedical Imaging·Abishek Arora, Neeta Bhagat
Apr 1, 2010·PET Clinics·Jacob G Dubroff, Andrew B Newberg
Jun 10, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matthias T WyssBruno Weber
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D A BenaronD K Stevenson
Apr 14, 2005·Angewandte Chemie·Hideki YorimitsuEiichi Nakamura
Apr 19, 2007·Chemistry, an Asian Journal·Hideki YorimitsuEiichi Nakamura

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