Metabolic Messengers: fibroblast growth factor 15/19

Nature Metabolism
Raffaella Maria Gadaleta, Antonio Moschetta

Abstract

Fibroblast growth factor (FGF) 15 in mice and its human orthologue FGF19 (together denoted FGF15/19) are gut hormones that control homeostasis of bile acids and glucose during the transition from the fed to the fasted state. Apart from its central role in the regulation of bile acid homeostasis, FGF15/19 is now recognized as a transversal metabolic coordinator at the crossroads of the gut, liver, brain and white adipose tissue. Dysregulation of FGF15/19 signalling may contribute to the pathogenesis of several diseases affecting the gut-liver axis and to metabolic diseases. Here, we provide an overview of current knowledge of the physiological roles of the enterokine FGF15/19 and highlight commonalities and differences between the two orthologues. We also discuss the putative therapeutic potential in areas of unmet medical need-such has cholestatic liver diseases and non-alcoholic steatohepatitis, for which FGF19 is being tested in ongoing clinical trials-as well as the possibility of using FGF19 for the treatment of obesity and type II diabetes.

References

Feb 5, 1999·Biochimica Et Biophysica Acta·T NishimuraN Itoh
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·M NittaB Shan
Oct 12, 2004·Trends in Genetics : TIG·Nobuyuki Itoh, David M Ornitz
May 20, 2005·The Journal of Clinical Investigation·Alexei KharitonenkovArmen B Shanafelt
Aug 3, 2005·The Journal of Clinical Investigation·Shinji ItoYo-Ichi Nabeshima
Oct 31, 2006·Nature Medicine·Mihwa ChoiSteven A Kliewer
Aug 19, 2007·World Journal of Gastroenterology : WJG·Wolfgang WistubaThomas Langmann
Aug 23, 2007·The Journal of Biological Chemistry·Xinle WuYang Li
Aug 28, 2007·Journal of Lipid Research·Insook KimFrank J Gonzalez
Aug 9, 2008·Endocrinology·Tamer CoskunAlexei Kharitonenkov
Dec 17, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kwang-Hoon SongJohn Y L Chiang
Feb 3, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Frank G SchaapPeter L M Jansen
Feb 25, 2009·The Journal of Biological Chemistry·Dong-Ju Shin, Timothy F Osborne
Feb 28, 2009·Nature Reviews. Drug Discovery·Andrew Beenken, Moosa Mohammadi
May 12, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Julian R F WaltersCarel W le Roux
Dec 17, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M ReicheM Fasshauer
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ken-ichi TomiyamaYo-ichi Nabeshima
Jan 23, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tim C M A SchreuderFrank G Schaap
Mar 18, 2010·The Journal of Biological Chemistry·Daniel R SchmidtDavid J Mangelsdorf
Jul 30, 2010·Molecular Endocrinology·Klementina Fon TacerSteven A Kliewer
Aug 5, 2010·Diabetes·Ffolliott M FisherEleftheria Maratos-Flier
Nov 9, 2010·Inflammatory Bowel Diseases·Martin LenicekLibor Vitek
Nov 26, 2010·Journal of Lipid Research·Anne S HenkelRichard M Green
Jun 7, 2011·Cell Metabolism·Matthew J PotthoffSteven A Kliewer
Sep 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Serge J L B ZweersFrank G Schaap
Jan 24, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rama PaiDonna Dambach
Mar 8, 2012·Advances in Experimental Medicine and Biology·Benjamin C Lin, Luc R Desnoyers
Apr 3, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bo KongGrace L Guo
May 9, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Masaaki MiyataYasushi Yamazoe
May 23, 2012·PloS One·Dorothy M FrenchLuc R Desnoyers
Oct 6, 2012·The Journal of Biological Chemistry·Serkan KirDavid J Mangelsdorf

❮ Previous
Next ❯

Citations

Nov 1, 2020·Cellular and Molecular Gastroenterology and Hepatology·Shengmin YanXiao-Ming Yin
Feb 27, 2021·Progress in Lipid Research·Stefano FiorucciMichele Biagioli
Mar 28, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Katrin Panzitt, Martin Wagner
Apr 15, 2021·Expert Opinion on Drug Discovery·Stefano FiorucciEleonora Distrutti
May 7, 2021·Cellular and Molecular Gastroenterology and Hepatology·Noga KorenfeldIdo Goldstein
May 25, 2021·JHEP Reports : Innovation in Hepatology·Cristiana BiancoLuca Valenti
Aug 9, 2021·Journal of Hepatology·Raffaella Maria Gadaleta, Antonio Moschetta
Sep 8, 2021·Journal of Crohn's & Colitis·Arno R BourgonjeRinse K Weersma

❮ Previous
Next ❯

Methods Mentioned

BETA
gastric-bypass

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.