Metabolic Microenvironments Drive Microbial Differentiation and Antibiotic Resistance.

Trends in Genetics : TIG
Tatyana L PovolotskyIlana Kolodkin-Gal

Abstract

For bacteria, the transition from unicellular entities to multicellular biofilm communities generates distinct metabolic microenvironments. Dynamic and programmed metabolic responses allow the biofilms to react to local changes in nutrient levels. Moreover, metabolic adaptations contribute to phenotypic antibiotic resistance of the community, suggesting novel therapeutic approaches to target biofilms.

Citations

Feb 16, 2021·Frontiers in Microbiology·Ruchika Vinod JoshiRiti Mann

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