Metabolic models of selection response

Journal of Theoretical Biology
P D Keightley

Abstract

Consequences of directional selection on metabolic flux are explored in models for which variation in flux among individuals is generated by segregation of allelic variants at enzyme activity loci. The pattern of selection response is strongly affected by the presence of genetic dominance and epistasis, which are automatically generated in metabolic systems. The expected magnitudes of dominance and epistasis effects on flux are evaluated. Small differences in enzyme activity generate little dominance, but a null allele will tend to be recessive for the pathway in which it occurs and for metabolically distant pathways. Epistasis is found to be greatest in short pathways in which large differences in enzyme activity occur. Under divergent artificial selection asymmetrical responses can occur due to the presence of directional dominance and epistasis, and lead to departures from the classic infinitesimal model of quantitative genetic variation. The effects of epistasis and dominance are in opposite directions, however, and partially cancel each other out in a diploid population.

Citations

Nov 17, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Julie B FiévetDominique de Vienne
Dec 8, 2004·Genetics·Homayoun C Bagheri, Günter P Wagner
Nov 26, 2010·Genetics·Aneil F Agrawal, Michael C Whitlock
May 12, 2007·Evolution; International Journal of Organic Evolution·Derek A Roff
Feb 2, 2002·Nature Reviews. Genetics·N H Barton, P D Keightley
Feb 14, 2004·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·J Yu, R Bernardo
Sep 15, 2005·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Homayoun C Bagheri
Dec 1, 2006·Evolution; International Journal of Organic Evolution·Derek A Roff, Kevin Emerson
Jun 16, 2007·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Mathilde CausseFrédéric Hospital
Jun 15, 2007·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·D A TabanaoR Bernardo
Feb 27, 2007·Nature Genetics·Lukasz Jasnos, Ryszard Korona
Dec 5, 2013·Evolution; International Journal of Organic Evolution·Thomas F Hansen
Oct 15, 2013·Journal of Evolutionary Biology·R K Vijendravarma, T J Kawecki
Nov 25, 2004·European Journal of Biochemistry·Sébastien LionDominique de Vienne
Jun 22, 1999·Journal of Theoretical Biology·T J Van Dooren
Mar 19, 2015·Genetics·Jacqueline L Sztepanacz, Mark W Blows
Jun 6, 2003·Mathematical Biosciences·Homayoun Bagheri-ChaichianGünter P Wagner
Jun 12, 2010·Trends in Ecology & Evolution·Aneil F Agrawal, Michael C Whitlock

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Xiao Yi, Antony M Dean
Methods : a Companion to Methods in Enzymology
O Monasterio
Journal of Theoretical Biology
T Höfer, R Heinrich
© 2021 Meta ULC. All rights reserved