Metabolic networks in epilepsy by MR spectroscopic imaging.

Acta Neurologica Scandinavica
J W PanSusan Spencer

Abstract

The concept of an epileptic network has long been suggested from both animal and human studies of epilepsy. Based on the common observation that the MR spectroscopic imaging measure of NAA/Cr is sensitive to neuronal function and injury, we use this parameter to assess for the presence of a metabolic network in mesial temporal lobe epilepsy (MTLE) patients. A multivariate factor analysis is performed with controls and MTLE patients, using NAA/Cr measures from 12 loci: the bilateral hippocampi, thalami, basal ganglia, and insula. The factor analysis determines which and to what extent these loci are metabolically covarying. We extract two independent factors that explain the data's variability in control and MTLE patients. In controls, these factors characterize a 'thalamic' and 'dominant subcortical' function. The MTLE patients also exhibit a 'thalamic' factor, in addition to a second factor involving the ipsilateral insula and bilateral basal ganglia. These data suggest that MTLE patients demonstrate a metabolic network that involves the thalami, also seen in controls. The MTLE patients also display a second set of metabolically covarying regions that may be a manifestation of the epileptic network that characterizes limbic se...Continue Reading

References

Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
May 23, 1998·NMR in Biomedicine·H P HetheringtonB R Newcomer
Sep 17, 1999·Neurology·R KuznieckyF Gilliam
Nov 26, 2003·Epilepsia·Susana B MoryFernando Cendes
Aug 27, 2004·Epilepsia·Krisztina BenedekHarry T Chugani
Nov 17, 2004·Annals of Neurology·Jullie W Pan, Kan Takahashi
Mar 3, 2005·Acta Neurologica Scandinavica·J W PanH P Hetherington
Sep 28, 2005·Neurology·S S SpencerUNKNOWN Multicenter Study of Epilepsy Surgery
Jan 13, 2006·Annals of Neurology·Anthony B WaitesGraeme D Jackson
Mar 15, 2006·Epilepsia·Theodore H SchwartzMichael R Sperling
Aug 30, 2008·Epilepsia·Susanne Aull-WatschingerChristoph Baumgartner

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Citations

Feb 4, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Sandy R ShultzRuben I Kuzniecky
Apr 20, 2014·AJNR. American Journal of Neuroradiology·Q XuG Lu
Jun 10, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Anto Bagić
Mar 8, 2017·Epilepsia·Wolfgang MuhlhoferRobert Knowlton
Jul 31, 2013·Epilepsia·Jullie W PanDennis D Spencer

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