Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women

International Journal of Cancer. Journal International Du Cancer
G C KabatT E Rohan

Abstract

Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes and homeostasis model-insulin resistance (HOMA-IR-a marker of insulin resistance) with risk of colorectal cancer in over 21,000 women in the Women's Health Initiative CVD Biomarkers subcohort. Women were cross-classified by BMI (18.5-<25.0, 25.0-<30.0 and ≥30.0 kg/m2 ) and presence of the metabolic syndrome into 6 phenotypes: metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy overweight (MHOW), metabolically unhealthy overweight (MUOW), metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO). Neither BMI nor presence of the metabolic syndrome was associated with risk of colorectal cancer, whereas waist circumference showed a robust positive association. Relative to the MHNW phenotype, the MUNW phenotype was associated with increased risk, whereas no other phenotype showed an association. Furthermore, HOMA-IR was not associated with increased risk. Overall, our results do not support a ...Continue Reading

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Citations

Jun 2, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Chien-Ju LinTzu Lin Yeh
Oct 14, 2018·Nature Reviews. Gastroenterology & Hepatology·Marc J Gunter, Elio Riboli
Nov 11, 2019·BMC Veterinary Research·Keidylania Costa-SantosAlessandra Estrela-Lima
Nov 27, 2020·International Journal of Environmental Research and Public Health·Jinsun KimByungmi Kim
Aug 29, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Meghan B SkibaCynthia A Thomson
Jan 31, 2021·International Journal of Molecular Sciences·Ji-Won HeoMi-Kyung Sung
Feb 11, 2021·Cancer Prevention Research·Bethina LiuAndrew J Dannenberg

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