Metabolic Pancreatitis: Pancreatic Steatosis, Hypertriglyceridemia, and Associated Chronic Pancreatitis in 3 Patients with Metabolic Syndrome

Case Reports in Gastroenterology
Constantine Melitas, Mick Meiselman

Abstract

Obesity, insulin resistance, and metabolic syndrome continue to increase in prevalence. Hypertriglyceridemia is commonly associated and represents a valuable marker of metabolic syndrome. An increase in subcutaneous fat deposition places patients at risk for visceral adipose deposition in sites such as the liver, heart, and pancreas. Pancreatic steatosis in the setting of metabolic syndrome is a rapidly emerging entity whose clinical spectrum remains to be defined. Hypertriglyceridemia is an accepted cause of acute pancreatitis but its role in chronic pancreatic injury remains to be explored. We present 3 patients with chronic abdominal pain and pancreatic steatosis in the setting of underlying metabolic syndrome with hypertriglyceridemia. These cases were identified in one endoscopic ultrasonographer's practice over a 12-month period. Each patient had documented hypertriglyceridemia but no history of acute hypertriglyceride-induced pancreatitis. A history of significant alcohol exposure was carefully excluded. Each patient underwent endoscopic ultrasonography (EUS) which proved critical in delineating the spectrum of chronic pancreatic injury. Each of our patients had EUS documentation of pancreatic steatosis and sufficient cr...Continue Reading

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Citations

Jul 26, 2019·Current Opinion in Gastroenterology·Resham Ramkissoon, Timothy B Gardner
Jun 12, 2019·The American Journal of Gastroenterology·Resham Ramkissoon, Timothy B Gardner
Jan 13, 2021·Journal of Clinical Medicine·Frank U WeissMarkus M Lerch
Aug 28, 2021·World Journal of Clinical Cases·Cheng-Lei ZhangYi Yang

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BETA
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