Metabolic Perturbation and Potential Markers in Patients with Esophageal Cancer

Gastroenterology Research and Practice
Xianlan ZhuLianzhen Yu

Abstract

Clinical diagnosis of esophageal cancer (EC) at early stage is rather difficult. This study aimed to profile the molecules in serum and tissue and identify potential biomarkers in patients with EC. A total of 64 volunteers were recruited, and 83 samples (24 EC serum samples, 21 serum controls, 19 paired EC tissues, and corresponding tumor-adjacent tissues) were analyzed. The gas chromatography time-of-flight mass spectrometry (GC/TOF-MS) was employed, and principal component analysis was used to reveal the discriminatory metabolites and identify the candidate markers of EC. A total of 41 in serum and 36 identified compounds in tissues were relevant to the malignant prognosis. A marked metabolic reprogramming of EC was observed, including enhanced anaerobic glycolysis and glutaminolysis, inhibited tricarboxylic acid (TCA) cycle, and altered lipid metabolism and amino acid turnover. Based on the potential markers of glucose, glutamic acid, lactic acid, and cholesterol, the receiver operating characteristic (ROC) curves indicated good diagnosis and prognosis of EC. EC patients showed distinct reprogrammed metabolism involved in glycolysis, TCA cycle, glutaminolysis, and fatty acid metabolism. The pivotal molecules in the metabolic...Continue Reading

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Citations

Dec 4, 2019·Expert Review of Gastroenterology & Hepatology·Jiaying YuLiyan Liu
Mar 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Louise Y FongCarlo M Croce
Oct 31, 2020·Frontiers in Oncology·Gang DongShiyao Chen
Mar 25, 2021·Critical Reviews in Analytical Chemistry·Younes AftabiAbolghasem Jouyban

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Methods Mentioned

BETA
surgical resection
nuclear magnetic resonance
NMR

Software Mentioned

DA
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