Metabolic perturbations associated with the consumption of a ketogenic medium-chain TAG diet in dogs with idiopathic epilepsy

The British Journal of Nutrition
Tsz Hong LawElizabeth Want

Abstract

Consumption of diets containing medium-chain TAG (MCT) has been shown to confer neuroprotective effects. We aim to identify the global metabolic perturbations associated with consumption of a ketogenic diet (medium-chain TAG diet (MCTD)) in dogs with idiopathic epilepsy. We used ultra-performance liquid chromatography-MS (UPLC-MS) to generate metabolic and lipidomic profiles of fasted canine serum and made comparisons between the MCTD and standardised placebo diet phases. We identified metabolites that differed significantly between diet phases using metabolite fragmentation profiles generated by tandem MS (UPLC-MS/MS). Consumption of the MCTD resulted in significant differences in serum metabolic profiles when compared with the placebo diet, where sixteen altered lipid metabolites were identified. Consumption of the MCTD resulted in reduced abundances of palmitoylcarnitine, octadecenoylcarnitine, stearoylcarnitine and significant changes, both reduced and increased abundances, of phosphatidylcholine (PC) metabolites. There was a significant increase in abundance of the saturated C17 : 0 fatty acyl moieties during the MCTD phase. Lysophosphatidylcholine (17 : 0) (P=0·01) and PC (17:0/20:4) (P=0·03) were both significantly highe...Continue Reading

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Citations

Apr 16, 2020·Journal of Veterinary Internal Medicine·Benjamin A BerkHolger A Volk
Mar 15, 2019·Epilepsia Open·Susan A MasinoBeth Zupec-Kania
Jan 9, 2021·Frontiers in Veterinary Science·Rachel PillaHolger Andreas Volk
Jul 6, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Henri F Avela, Heli Sirén
May 8, 2021·Journal of Veterinary Internal Medicine·Gareth Michael Couper JonesRowena Mary Anne Packer

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