PMID: 16614407Apr 15, 2006Paper

Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women

The Journal of Nutrition
Liwei GuThomas M Badger

Abstract

Various physiologic effects of soy food consumption have been attributed to the estrogenic actions of isoflavones. The order of estrogen receptor binding potency of soy-derived isoflavone aglycones is equol > genistein > daidzein, and their conjugates are less potent. Because the metabolic profile may be an important determinant of bioactivity after soy intake, we studied the serum and urine isoflavone concentrations in 3 animal models and compared them with isoflavone profiles in women. Female Sprague-Dawley rats, Hampshire/Duroc Cross pigs, cynomolgus monkeys, and women were fed diets containing soy protein isolate. Isoflavones and their metabolites were measured by LC-MS or electrochemical detection. Equol represented approximately 77 and 52% (molar ratio) of summed serum isoflavones (isoflavones plus metabolites) in rats and cynomolgus monkeys, respectively. Equol was undetectable in pig serum and human plasma, but daidzein and genistein contributed >88% of summed circulating isoflavones. Monkey and rat urine contained high levels of aglycones (>85% and >32%, respectively), whereas pigs and women excreted isoflavone mainly in the form of glucuronides (>80%), with <10% as aglycones. Isoflavones in human plasma were predomina...Continue Reading

References

Apr 28, 1997·Biochemical and Biophysical Research Communications·C K Wong, W M Keung
Dec 16, 1998·The American Journal of Clinical Nutrition·M S AnthonyJ K Williams
Oct 6, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·C O CiminoT M Badger
May 15, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·N M Brown, K D Setchell
Jul 19, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jaya Bharathi Vaidyanathan, Thomas Walle
Oct 9, 2002·The Journal of Nutrition·Michael S MortonBronwen A J Evans
Dec 7, 2002·The Journal of Nutrition·Kenneth D R SetchellEva Lydeking-Olsen
Apr 4, 2003·Analytical Biochemistry·Philip B GraceSheila A Bingham
Jul 4, 2003·The Journal of Nutrition·Robert M BlairThomas B Clarkson
Dec 19, 2003·Biology of Reproduction·Trent D LundRobert J Handa
Dec 20, 2003·The American Journal of Clinical Nutrition·Janice L BlanaruHope A Weiler
Jul 9, 2004·JAMA : the Journal of the American Medical Association·Sanne Kreijkamp-KaspersYvonne T van der Schouw
Jan 5, 2005·BioFactors·Herman AdlercreutzJosé Penalvo-Garcia
Aug 18, 2005·Journal of Agricultural and Food Chemistry·Liwei GuThomas M Badger

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Citations

Sep 21, 2006·Journal of the National Cancer Institute·Mark MessinaJohanna W Lampe
Jun 2, 2007·Expert Opinion on Drug Metabolism & Toxicology·Zhongqiu Liu, Ming Hu
Apr 10, 2009·The American Journal of Clinical Nutrition·Thomas M BadgerMartin J Ronis
May 12, 2009·Journal of Clinical Biochemistry and Nutrition·Yoko TakahashiTakashi Ide
Apr 10, 2012·Immunologic Research·Madhan MasilamaniHugh A Sampson
Dec 8, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mark Messina
May 19, 2012·International Journal of Food Sciences and Nutrition·Yasuhiro AbiruKyosuke Masaki
Dec 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Chung-Ping YuYu-Chi Hou
Feb 2, 2013·Animal : an International Journal of Animal Bioscience·C FarmerG S Gilani
Jan 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Urszula CegiełaGrażyna Zgórka
Oct 14, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jin-Ran ChenKartik Shankar
Jan 7, 2017·Experimental Biology and Medicine·Kelly E MercerMartin Jj Ronis
Jan 6, 2018·Nutrients·Gianluca Rizzo, Luciana Baroni
Jan 7, 2020·Current Drug Metabolism·Pooja Rathaur, Kaid Johar Sr
Jun 2, 2009·American Journal of Primatology·Janice D WagnerJay R Kaplan
Jul 22, 2008·The Journal of Nutrition·Juliane BiegerSiegfried Wolffram
Jun 7, 2008·Experimental Biology and Medicine·Anne Ørgaard, Lotte Jensen
Oct 8, 2008·Molecular Nutrition & Food Research·Kelly R WalshMark L Failla
Jul 16, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yulin MaDerek A Schreihofer
Oct 4, 2013·The Journal of Nutrition·Kenneth D R SetchellBevan Hokin
Jun 10, 2011·Annals of Nutrition & Metabolism·G Sarwar GilaniGerard M Cooke
Aug 11, 2012·Journal of Nutritional Science and Vitaminology·Seiwa MichiharaYukio Kawamura
Mar 15, 2015·Bioscience, Biotechnology, and Biochemistry·Mina FujitaniTaro Kishida
Jun 24, 2008·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Rajpal S Tomar, Renee Shiao
Jun 4, 2010·The Journal of Nutrition·Kenneth D R Setchell, Carlo Clerici
Oct 1, 2011·The American Journal of Clinical Nutrition·Kenneth D R SetchellMark J Messina
Mar 1, 2010·Animal : an International Journal of Animal Bioscience·C FarmerA V Capuco
Jan 1, 2009·Drug Testing and Analysis·Adrian A FrankeLaurie J Custer
Mar 29, 2014·Molecular Nutrition & Food Research·Mohammed A IslamIvonne M C M Rietjens
Sep 3, 2014·Experimental Biology and Medicine·Martin Jj RonisThomas M Badger

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