Metabolic Portraits of Breast Cancer by HR MAS MR Spectroscopy of Intact Tissue Samples

Metabolites
Tonje H HaukaasTone Frost Bathen

Abstract

Despite progress in early detection and therapeutic strategies, breast cancer remains the second leading cause of cancer-related death among women globally. Due to the heterogeneity and complexity of tumor biology, breast cancer patients with similar diagnosis might have different prognosis and response to treatment. Thus, deeper understanding of individual tumor properties is necessary. Cancer cells must be able to convert nutrients to biomass while maintaining energy production, which requires reprogramming of central metabolic processes in the cells. This phenomenon is increasingly recognized as a potential target for treatment, but also as a source for biomarkers that can be used for prognosis, risk stratification and therapy monitoring. Magnetic resonance (MR) metabolomics is a widely used approach in translational research, aiming to identify clinically relevant metabolic biomarkers or generate novel understanding of the molecular biology in tumors. Ex vivo proton high-resolution magic angle spinning (HR MAS) MR spectroscopy is widely used to study central metabolic processes in a non-destructive manner. Here we review the current status for HR MAS MR spectroscopy findings in breast cancer in relation to glucose, amino ac...Continue Reading

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Citations

Aug 10, 2017·Metabolites·Madhu Basetti
Feb 22, 2018·International Journal of Molecular Sciences·Marcella Regina CardosoSophie Françoise Mauricette Derchain
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Anup PaulRaja Roy
Jun 12, 2019·NMR in Biomedicine·Kanchan SonkarKristine Glunde
Aug 14, 2018·PET Clinics·Gary A Ulaner, David M Schuster

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Methods Mentioned

BETA
protein array
genetic modifications
biopsies
biopsy
xenograft
xenografts

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